Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C192138> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- NCIT_C192138 IAO_0000115 "A polyethylene glycol (PEG)-conjugated mutein form of the cytokine interleukin-2 (IL-2), with potential and specific activity on enhancing proliferation, survival and anti-tumor activity of engineered orthoIL-2Rb-expressing CAR T-cells. Upon subcutaneous administration, pegylated orthogonal (ortho) IL-2 STK-009 specifically targets and binds to mutated orthoIL-2Rbeta (hoRbeta; hoRb) that is specifically expressed on certain engineered CAR T-cells. This induces selective proliferation, survival, and cytotoxic function of orthoIL-2Rbeta-expressing CAR T-cells, which enhances tumor cell killing and decreases tumor cell proliferation. Pegylation of IL-2 protects the cytokine from degradation. STK-009 does not bind to the wild type (WT) IL-2b receptor and does not activate IL-2-mediated signaling in bystander T- and NK-cells, thereby limiting systemic toxicity." @default.
- NCIT_C192138 NCIT_NHC0 "C192138" @default.
- NCIT_C192138 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C192138 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C192138 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192138 NCIT_P107 "Pegylated Orthogonal IL-2 STK-009" @default.
- NCIT_C192138 NCIT_P108 "Pegylated Orthogonal IL-2 STK-009" @default.
- NCIT_C192138 NCIT_P208 "CL1905607" @default.
- NCIT_C192138 NCIT_P322 "CTRP" @default.
- NCIT_C192138 NCIT_P322 "GDC" @default.
- NCIT_C192138 NCIT_P399 "811634" @default.
- NCIT_C192138 NCIT_R124 NCIT_C17828 @default.
- NCIT_C192138 NCIT_R124 NCIT_C18992 @default.
- NCIT_C192138 NCIT_R124 NCIT_C19143 @default.
- NCIT_C192138 NCIT_R124 NCIT_C21124 @default.
- NCIT_C192138 NCIT_R124 NCIT_C40702 @default.
- NCIT_C192138 NCIT_R124 NCIT_C45547 @default.
- NCIT_C192138 NCIT_R125 NCIT_C16395 @default.
- NCIT_C192138 NCIT_R125 NCIT_C17710 @default.
- NCIT_C192138 NCIT_R125 NCIT_C17828 @default.
- NCIT_C192138 NCIT_R125 NCIT_C17937 @default.
- NCIT_C192138 NCIT_R125 NCIT_C18081 @default.
- NCIT_C192138 NCIT_R125 NCIT_C18095 @default.
- NCIT_C192138 NCIT_R125 NCIT_C18839 @default.
- NCIT_C192138 NCIT_R125 NCIT_C20480 @default.
- NCIT_C192138 NCIT_R125 NCIT_C20751 @default.
- NCIT_C192138 NCIT_R125 NCIT_C21049 @default.
- NCIT_C192138 NCIT_R125 NCIT_C21050 @default.
- NCIT_C192138 NCIT_R125 NCIT_C21124 @default.
- NCIT_C192138 NCIT_R125 NCIT_C26280 @default.
- NCIT_C192138 NCIT_R125 NCIT_C28498 @default.
- NCIT_C192138 NCIT_R125 NCIT_C40767 @default.
- NCIT_C192138 NCIT_R125 NCIT_C40833 @default.
- NCIT_C192138 NCIT_R125 NCIT_C40912 @default.
- NCIT_C192138 NCIT_R146 NCIT_C104679 @default.
- NCIT_C192138 NCIT_R146 NCIT_C21176 @default.
- NCIT_C192138 NCIT_R146 NCIT_C26548 @default.
- NCIT_C192138 normalizedInformationContent "100" @default.
- NCIT_C192138 referenceCount "1" @default.
- NCIT_C192138 hasExactSynonym "OrthoIL-2 STK-009" @default.
- NCIT_C192138 hasExactSynonym "Orthogonal IL-2 Ligand STK-009" @default.
- NCIT_C192138 hasExactSynonym "Orthogonal IL-2 STK-009" @default.
- NCIT_C192138 hasExactSynonym "Pegylated IL-2 Mutein STK-009" @default.
- NCIT_C192138 hasExactSynonym "Pegylated Orthogonal IL-2 STK-009" @default.
- NCIT_C192138 hasExactSynonym "STK 009" @default.
- NCIT_C192138 hasExactSynonym "STK-009" @default.
- NCIT_C192138 hasExactSynonym "STK009" @default.
- NCIT_C192138 inSubset NCIT_C116977 @default.
- NCIT_C192138 inSubset NCIT_C116978 @default.
- NCIT_C192138 inSubset NCIT_C128784 @default.
- NCIT_C192138 inSubset NCIT_C157711 @default.
- NCIT_C192138 inSubset NCIT_C157712 @default.
- NCIT_C192138 inSubset NCIT_C176424 @default.
- NCIT_C192138 type Class @default.
- NCIT_C192138 isDefinedBy ncit.owl @default.
- NCIT_C192138 label "Pegylated Orthogonal IL-2 STK-009" @default.
- NCIT_C192138 subClassOf NCIT_C1283 @default.
- NCIT_C192138 subClassOf NCIT_C1908 @default.
- NCIT_C192138 subClassOf NCIT_C1909 @default.
- NCIT_C192138 subClassOf NCIT_C192138 @default.
- NCIT_C192138 subClassOf NCIT_C307 @default.
- NCIT_C192138 subClassOf NCIT_C308 @default.
- NCIT_C192138 subClassOf NCIT_C587 @default.
- NCIT_C192138 subClassOf NCIT_C593 @default.