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- NCIT_C192170 IAO_0000115 "An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR), with potential antineoplastic activity. Upon oral administration, FGFR inhibitor ET0111 binds to and inhibits FGFR, which results in the inhibition of FGFR-mediated signal transduction pathways. This inhibits proliferation in FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation and survival." @default.
- NCIT_C192170 NCIT_A7 NCIT_C17297 @default.
- NCIT_C192170 NCIT_NHC0 "C192170" @default.
- NCIT_C192170 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192170 NCIT_P108 "FGFR Inhibitor ET0111" @default.
- NCIT_C192170 NCIT_P208 "CL1905582" @default.
- NCIT_C192170 NCIT_P322 "GDC" @default.
- NCIT_C192170 NCIT_P399 "811335" @default.
- NCIT_C192170 normalizedInformationContent "100" @default.
- NCIT_C192170 referenceCount "1" @default.
- NCIT_C192170 hasExactSynonym "ET 0111" @default.
- NCIT_C192170 hasExactSynonym "ET-0111" @default.
- NCIT_C192170 hasExactSynonym "ET0111" @default.
- NCIT_C192170 hasExactSynonym "FGFR Inhibitor ET0111" @default.
- NCIT_C192170 inSubset NCIT_C128784 @default.
- NCIT_C192170 inSubset NCIT_C157711 @default.
- NCIT_C192170 inSubset NCIT_C157712 @default.
- NCIT_C192170 inSubset NCIT_C176424 @default.
- NCIT_C192170 type Class @default.
- NCIT_C192170 isDefinedBy ncit.owl @default.
- NCIT_C192170 label "FGFR Inhibitor ET0111" @default.
- NCIT_C192170 subClassOf NCIT_C129824 @default.
- NCIT_C192170 subClassOf NCIT_C129825 @default.
- NCIT_C192170 subClassOf NCIT_C1404 @default.
- NCIT_C192170 subClassOf NCIT_C155727 @default.
- NCIT_C192170 subClassOf NCIT_C163758 @default.
- NCIT_C192170 subClassOf NCIT_C164035 @default.
- NCIT_C192170 subClassOf NCIT_C1908 @default.
- NCIT_C192170 subClassOf NCIT_C1909 @default.
- NCIT_C192170 subClassOf NCIT_C192170 @default.
- NCIT_C192170 subClassOf NCIT_C1967 @default.
- NCIT_C192170 subClassOf NCIT_C2189 @default.
- NCIT_C192170 subClassOf NCIT_C274 @default.
- NCIT_C192170 subClassOf NCIT_C471 @default.