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- NCIT_C192171 IAO_0000115 "A bifunctional fusion protein composed of a humanized anti-programmed death ligand 1 (PD-L1) nanobody fused to a mutant form of the human transforming growth factor beta (TGFbeta) receptor type II (TGFbetaRII), with potential antineoplastic and immune checkpoint modulating activities. Upon administration of anti-PD-L1/TGFbetaRII fusion protein 6MW3511, the TGFbetaRII moiety targets, binds to and neutralizes TGFbeta while the anti-PD-L1 nanobody moiety simultaneously targets, binds to, and inhibits the activity of PD-L1 on the tumor cell. This prevents both TGFbeta- and PD-L1-mediated immuno-suppressive pathways signaling, and increases natural killer (NK) cell and cytotoxic T-lymphocyte (CTL) activities. This restores and enhances anti-tumor immune responses and inhibits tumor cell proliferation in susceptible tumor cells. TGFbeta and PD-L1 are both upregulated in certain types of cancers and play key roles in tumor immune suppression; their overexpression is associated with increased evasion of immune surveillance and contributes to poor prognosis. The TGFbetaRII moiety is modified to enhance the stability of the agent." @default.
- NCIT_C192171 NCIT_A7 NCIT_C20457 @default.
- NCIT_C192171 NCIT_A7 NCIT_C20458 @default.
- NCIT_C192171 NCIT_A7 NCIT_C20459 @default.
- NCIT_C192171 NCIT_A7 NCIT_C96024 @default.
- NCIT_C192171 NCIT_NHC0 "C192171" @default.
- NCIT_C192171 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192171 NCIT_P108 "Anti-PD-L1/TGFbetaRII Fusion Protein 6MW3511" @default.
- NCIT_C192171 NCIT_P208 "CL1905575" @default.
- NCIT_C192171 NCIT_P322 "GDC" @default.
- NCIT_C192171 NCIT_P399 "811339" @default.
- NCIT_C192171 normalizedInformationContent "100" @default.
- NCIT_C192171 referenceCount "1" @default.
- NCIT_C192171 hasExactSynonym "6MW3511" @default.
- NCIT_C192171 hasExactSynonym "Anti-PD-L1 Nanobody/TGFbetaRII Mutant Fusion Protein 6MW3511" @default.
- NCIT_C192171 hasExactSynonym "Anti-PD-L1/TGFbetaRII Bifunctional Fusion Protein 6MW3511" @default.
- NCIT_C192171 hasExactSynonym "Anti-PD-L1/TGFbetaRII Fusion Protein 6MW3511" @default.
- NCIT_C192171 inSubset NCIT_C128784 @default.
- NCIT_C192171 inSubset NCIT_C157711 @default.
- NCIT_C192171 inSubset NCIT_C157712 @default.
- NCIT_C192171 inSubset NCIT_C176424 @default.
- NCIT_C192171 type Class @default.
- NCIT_C192171 isDefinedBy ncit.owl @default.
- NCIT_C192171 label "Anti-PD-L1/TGFbetaRII Fusion Protein 6MW3511" @default.
- NCIT_C192171 subClassOf NCIT_C129820 @default.
- NCIT_C192171 subClassOf NCIT_C1908 @default.
- NCIT_C192171 subClassOf NCIT_C1909 @default.
- NCIT_C192171 subClassOf NCIT_C192171 @default.
- NCIT_C192171 subClassOf NCIT_C274 @default.
- NCIT_C192171 subClassOf NCIT_C308 @default.