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- NCIT_C192205 IAO_0000115 "A human immunoglobulin G1 (IgG1) Fc-silenced bispecific antibody directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PD1; PDCD1; CD279; programmed death 1) and lymphocyte activation gene 3 protein (LAG-3; LAG3; CD223), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-LAG-3/PD-1 bispecific antibody INCA32459 targets and binds to both PD-1 and LAG-3 expressed on T-cells and inhibits PD-1- and LAG-3-mediated downregulation of T-cell activation and proliferation. This may lead to cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. PD-1 and LAG-3 play key roles in suppressing T-cell activation and proliferation." @default.
- NCIT_C192205 NCIT_A7 NCIT_C104623 @default.
- NCIT_C192205 NCIT_A7 NCIT_C94697 @default.
- NCIT_C192205 NCIT_NHC0 "C192205" @default.
- NCIT_C192205 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192205 NCIT_P107 "Anti-LAG-3/PD-1 Bispecific Antibody INCA32459" @default.
- NCIT_C192205 NCIT_P108 "Anti-LAG-3/PD-1 Bispecific Antibody INCA32459" @default.
- NCIT_C192205 NCIT_P208 "CL1905551" @default.
- NCIT_C192205 NCIT_P322 "CTRP" @default.
- NCIT_C192205 NCIT_P322 "GDC" @default.
- NCIT_C192205 NCIT_P399 "811636" @default.
- NCIT_C192205 NCIT_R124 NCIT_C17710 @default.
- NCIT_C192205 NCIT_R124 NCIT_C17828 @default.
- NCIT_C192205 NCIT_R124 NCIT_C18219 @default.
- NCIT_C192205 NCIT_R124 NCIT_C19986 @default.
- NCIT_C192205 NCIT_R124 NCIT_C40474 @default.
- NCIT_C192205 normalizedInformationContent "100" @default.
- NCIT_C192205 referenceCount "1" @default.
- NCIT_C192205 hasExactSynonym "Anti-LAG-3/PD-1 Bispecific Antibody INCA32459" @default.
- NCIT_C192205 hasExactSynonym "Anti-LAG3/PD1 Bispecific Antibody INCA32459" @default.
- NCIT_C192205 hasExactSynonym "Anti-PD-1/Anti-LAG-3 Bispecific Antibody INCA32459" @default.
- NCIT_C192205 hasExactSynonym "Anti-PD-1/LAG-3 Bispecific Antibody INCA32459" @default.
- NCIT_C192205 hasExactSynonym "INCA 32459" @default.
- NCIT_C192205 hasExactSynonym "INCA-32459" @default.
- NCIT_C192205 hasExactSynonym "INCA32459" @default.
- NCIT_C192205 hasExactSynonym "PD-1 x LAG-3 Bispecific Antibody INCA32459" @default.
- NCIT_C192205 inSubset NCIT_C116977 @default.
- NCIT_C192205 inSubset NCIT_C116978 @default.
- NCIT_C192205 inSubset NCIT_C128784 @default.
- NCIT_C192205 inSubset NCIT_C157711 @default.
- NCIT_C192205 inSubset NCIT_C157712 @default.
- NCIT_C192205 inSubset NCIT_C176424 @default.
- NCIT_C192205 type Class @default.
- NCIT_C192205 isDefinedBy ncit.owl @default.
- NCIT_C192205 label "Anti-LAG-3/PD-1 Bispecific Antibody INCA32459" @default.
- NCIT_C192205 subClassOf NCIT_C124946 @default.
- NCIT_C192205 subClassOf NCIT_C128037 @default.
- NCIT_C192205 subClassOf NCIT_C129821 @default.
- NCIT_C192205 subClassOf NCIT_C129822 @default.
- NCIT_C192205 subClassOf NCIT_C134305 @default.
- NCIT_C192205 subClassOf NCIT_C141144 @default.
- NCIT_C192205 subClassOf NCIT_C143250 @default.
- NCIT_C192205 subClassOf NCIT_C1454 @default.
- NCIT_C192205 subClassOf NCIT_C163758 @default.
- NCIT_C192205 subClassOf NCIT_C1908 @default.
- NCIT_C192205 subClassOf NCIT_C1909 @default.
- NCIT_C192205 subClassOf NCIT_C192205 @default.
- NCIT_C192205 subClassOf NCIT_C200483 @default.
- NCIT_C192205 subClassOf NCIT_C20401 @default.
- NCIT_C192205 subClassOf NCIT_C274 @default.
- NCIT_C192205 subClassOf NCIT_C28227 @default.
- NCIT_C192205 subClassOf NCIT_C307 @default.
- NCIT_C192205 subClassOf NCIT_C308 @default.