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- NCIT_C192209 IAO_0000115 "A bispecific agent composed of a human immunoglobulin G4 (IgG4) monoclonal antibody targeting the cell surface antigen cluster of differentiation (CD228; melanotransferrin; MFI2; MELTF; p97) fused to a binding protein targeting the costimulatory receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD228/4-1BB bispecific agent SGN-BB228 simultaneously targets and binds to CD228 expressed on the surface of tumor cells and 4-1BB expressed on a variety of leukocyte subsets including activated T-lymphocytes. This crosslinks CD228-expressing tumor cells and 4-1BB-expressing T-cells, and activates 4-1BB signaling locally in the tumor microenvironment (TME). This results in cytotoxic T-cell co-stimulation, enhances T-lymphocyte-mediated anti-tumor activity and leads to cytotoxic T-cell-mediated lysis of CD228-expressing tumor cells. CD228, a cell-surfaced, glycosylphosphatidylinoitol (GPI)-anchored glycoprotein that belongs to the transferrin family of iron-binding proteins, is upregulated in certain tumor types including melanoma, mesothelioma and lung cancer. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity." @default.
- NCIT_C192209 NCIT_A7 NCIT_C105113 @default.
- NCIT_C192209 NCIT_A7 NCIT_C168793 @default.
- NCIT_C192209 NCIT_NHC0 "C192209" @default.
- NCIT_C192209 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192209 NCIT_P107 "Anti-CD228/4-1BB Bispecific Agent SGN-BB228" @default.
- NCIT_C192209 NCIT_P108 "Anti-CD228/4-1BB Bispecific Agent SGN-BB228" @default.
- NCIT_C192209 NCIT_P208 "CL1905547" @default.
- NCIT_C192209 NCIT_P322 "CTRP" @default.
- NCIT_C192209 NCIT_P322 "GDC" @default.
- NCIT_C192209 NCIT_P399 "811561" @default.
- NCIT_C192209 normalizedInformationContent "100" @default.
- NCIT_C192209 referenceCount "1" @default.
- NCIT_C192209 hasExactSynonym "Anti-CD228/4-1BB Bispecific Agent SGN-BB228" @default.
- NCIT_C192209 hasExactSynonym "Anti-CD228/4-1BB Bispecific Antibody-Anticalin Molecule" @default.
- NCIT_C192209 hasExactSynonym "Anti-CD228/Anti-4-1BB Bispecific Agent SGN-BB228" @default.
- NCIT_C192209 hasExactSynonym "Bispecific Antibody-Anticalin Fusion Protein SGN-BB228" @default.
- NCIT_C192209 hasExactSynonym "CD228 x 4-1BB Bispecific Agent SGN-BB228" @default.
- NCIT_C192209 hasExactSynonym "Mabcalin SGN-BB228" @default.
- NCIT_C192209 hasExactSynonym "PRS 346" @default.
- NCIT_C192209 hasExactSynonym "PRS-346" @default.
- NCIT_C192209 hasExactSynonym "PRS346" @default.
- NCIT_C192209 hasExactSynonym "SGN BB228" @default.
- NCIT_C192209 hasExactSynonym "SGN-BB228" @default.
- NCIT_C192209 hasExactSynonym "SGNBB228" @default.
- NCIT_C192209 inSubset NCIT_C116977 @default.
- NCIT_C192209 inSubset NCIT_C116978 @default.
- NCIT_C192209 inSubset NCIT_C128784 @default.
- NCIT_C192209 inSubset NCIT_C157711 @default.
- NCIT_C192209 inSubset NCIT_C157712 @default.
- NCIT_C192209 inSubset NCIT_C176424 @default.
- NCIT_C192209 type Class @default.
- NCIT_C192209 isDefinedBy ncit.owl @default.
- NCIT_C192209 label "Anti-CD228/4-1BB Bispecific Agent SGN-BB228" @default.
- NCIT_C192209 subClassOf NCIT_C129820 @default.
- NCIT_C192209 subClassOf NCIT_C1908 @default.
- NCIT_C192209 subClassOf NCIT_C1909 @default.
- NCIT_C192209 subClassOf NCIT_C192209 @default.
- NCIT_C192209 subClassOf NCIT_C192997 @default.
- NCIT_C192209 subClassOf NCIT_C274 @default.
- NCIT_C192209 subClassOf NCIT_C308 @default.