Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C192227> ?p ?o ?g. }
Showing items 1 to 44 of
44
with 100 items per page.
- NCIT_C192227 IAO_0000115 "An orally bioavailable, selective inhibitor of human fibroblast growth factor receptor 3 (FGFR3), with potential antineoplastic activity. Upon oral administration, FGFR3 inhibitor LOXO-435 specifically targets and binds to FGFR3, including FGFR3 gatekeeper resistance mutations. This blocks FGFR3-mediated signaling and leads to an inhibition of tumor cell proliferation in FGFR3-overexpressing cells. FGFR3, a receptor tyrosine kinase, is involved in angiogenesis and in the proliferation, differentiation, and survival of tumor cells. FGFR3 expression is associated with poor prognosis. It is overexpressed and/or mutated by certain tumor cell types." @default.
- NCIT_C192227 NCIT_A7 NCIT_C26129 @default.
- NCIT_C192227 NCIT_NHC0 "C192227" @default.
- NCIT_C192227 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192227 NCIT_P107 "FGFR3 Inhibitor LOXO-435" @default.
- NCIT_C192227 NCIT_P108 "FGFR3 Inhibitor LOXO-435" @default.
- NCIT_C192227 NCIT_P322 "CTRP" @default.
- NCIT_C192227 NCIT_P322 "GDC" @default.
- NCIT_C192227 NCIT_P399 "811885" @default.
- NCIT_C192227 normalizedInformationContent "100" @default.
- NCIT_C192227 referenceCount "1" @default.
- NCIT_C192227 hasExactSynonym "FGFR3 Inhibitor LOXO-435" @default.
- NCIT_C192227 hasExactSynonym "FGFR3 Inhibitor LY3866288" @default.
- NCIT_C192227 hasExactSynonym "LOX 24350" @default.
- NCIT_C192227 hasExactSynonym "LOX-24350" @default.
- NCIT_C192227 hasExactSynonym "LOX24350" @default.
- NCIT_C192227 hasExactSynonym "LOXO 435" @default.
- NCIT_C192227 hasExactSynonym "LOXO-435" @default.
- NCIT_C192227 hasExactSynonym "LOXO435" @default.
- NCIT_C192227 hasExactSynonym "LY 3866288" @default.
- NCIT_C192227 hasExactSynonym "LY-3866288" @default.
- NCIT_C192227 hasExactSynonym "LY3866288" @default.
- NCIT_C192227 inSubset NCIT_C116977 @default.
- NCIT_C192227 inSubset NCIT_C116978 @default.
- NCIT_C192227 inSubset NCIT_C128784 @default.
- NCIT_C192227 inSubset NCIT_C157711 @default.
- NCIT_C192227 inSubset NCIT_C157712 @default.
- NCIT_C192227 inSubset NCIT_C176424 @default.
- NCIT_C192227 type Class @default.
- NCIT_C192227 isDefinedBy ncit.owl @default.
- NCIT_C192227 label "FGFR3 Inhibitor LOXO-435" @default.
- NCIT_C192227 subClassOf NCIT_C129824 @default.
- NCIT_C192227 subClassOf NCIT_C129825 @default.
- NCIT_C192227 subClassOf NCIT_C1404 @default.
- NCIT_C192227 subClassOf NCIT_C155727 @default.
- NCIT_C192227 subClassOf NCIT_C163758 @default.
- NCIT_C192227 subClassOf NCIT_C164035 @default.
- NCIT_C192227 subClassOf NCIT_C1908 @default.
- NCIT_C192227 subClassOf NCIT_C1909 @default.
- NCIT_C192227 subClassOf NCIT_C192227 @default.
- NCIT_C192227 subClassOf NCIT_C1967 @default.
- NCIT_C192227 subClassOf NCIT_C2189 @default.
- NCIT_C192227 subClassOf NCIT_C274 @default.
- NCIT_C192227 subClassOf NCIT_C471 @default.