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- NCIT_C192641 IAO_0000115 "A trispecific antibody targeting hepatocyte growth factor receptor (HGFR; c-Met), epidermal growth factor receptor (EGFR), and vascular endothelial growth factor (VEGF), with potential anti-angiogenic and antineoplastic activities. Upon administration, anti-c-Met/EGFR/VEGF trispecific antibody TAVO412 simultaneously targets and binds to c-Met, EGFR and VEGF. The binding of TAVO412 to c-Met and EGFR expressed on tumor cells prevents receptor phosphorylation. This prevents the activation of both c-Met- and EGFR-mediated signaling pathways. The binding of TAVO412 to VEGF prevents both its binding to VEGF receptors (VEGFRs) and VEGF/VEGFR-mediated signaling. This inhibits the proliferation of vascular endothelial cells and prevents the growth and maintenance of tumor blood vessels, which leads to tumor cell death. In addition, TAVO412 induces Fc-mediated antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC). EGFR and c-Met, both upregulated and/or mutated in a variety of tumor cell types, play key roles in tumor cell proliferation. VEGF is overexpressed in a variety of cancer cells, and VEGF/VEGFR signaling plays an essential role in angiogenesis and the proliferation, survival, migration and differentiation of endothelial cells." @default.
- NCIT_C192641 NCIT_A7 NCIT_C129646 @default.
- NCIT_C192641 NCIT_A7 NCIT_C17068 @default.
- NCIT_C192641 NCIT_A7 NCIT_C18186 @default.
- NCIT_C192641 NCIT_NHC0 "C192641" @default.
- NCIT_C192641 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C192641 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192641 NCIT_P107 "Anti-c-Met/EGFR/VEGF Trispecific Antibody TAVO412" @default.
- NCIT_C192641 NCIT_P108 "Anti-c-Met/EGFR/VEGF Trispecific Antibody TAVO412" @default.
- NCIT_C192641 NCIT_P322 "CTRP" @default.
- NCIT_C192641 NCIT_P322 "GDC" @default.
- NCIT_C192641 NCIT_P399 "811452" @default.
- NCIT_C192641 NCIT_R124 NCIT_C17710 @default.
- NCIT_C192641 NCIT_R124 NCIT_C17828 @default.
- NCIT_C192641 NCIT_R124 NCIT_C18219 @default.
- NCIT_C192641 NCIT_R124 NCIT_C19986 @default.
- NCIT_C192641 NCIT_R124 NCIT_C40474 @default.
- NCIT_C192641 normalizedInformationContent "100" @default.
- NCIT_C192641 referenceCount "1" @default.
- NCIT_C192641 hasExactSynonym "Anti-c-Met/Anti-EGFR/Anti-VEGF Trispecific Antibody TAVO412" @default.
- NCIT_C192641 hasExactSynonym "Anti-c-Met/EGFR/VEGF Antibody TAVO412" @default.
- NCIT_C192641 hasExactSynonym "Anti-c-Met/EGFR/VEGF Trispecific Antibody TAVO412" @default.
- NCIT_C192641 hasExactSynonym "Anti-cMET/Anti-EGFR/Anti-VEGF Multi-specific Antibody TAVO412" @default.
- NCIT_C192641 hasExactSynonym "TAVO 412" @default.
- NCIT_C192641 hasExactSynonym "TAVO-412" @default.
- NCIT_C192641 hasExactSynonym "TAVO412" @default.
- NCIT_C192641 hasExactSynonym "Trispecific c-Met x EGFR x VEGF Antibody TAVO412" @default.
- NCIT_C192641 inSubset NCIT_C116977 @default.
- NCIT_C192641 inSubset NCIT_C116978 @default.
- NCIT_C192641 inSubset NCIT_C128784 @default.
- NCIT_C192641 inSubset NCIT_C157711 @default.
- NCIT_C192641 inSubset NCIT_C157712 @default.
- NCIT_C192641 inSubset NCIT_C176424 @default.
- NCIT_C192641 type Class @default.
- NCIT_C192641 isDefinedBy ncit.owl @default.
- NCIT_C192641 label "Anti-c-Met/EGFR/VEGF Trispecific Antibody TAVO412" @default.
- NCIT_C192641 subClassOf NCIT_C129821 @default.
- NCIT_C192641 subClassOf NCIT_C129822 @default.
- NCIT_C192641 subClassOf NCIT_C133878 @default.
- NCIT_C192641 subClassOf NCIT_C163758 @default.
- NCIT_C192641 subClassOf NCIT_C163952 @default.
- NCIT_C192641 subClassOf NCIT_C164000 @default.
- NCIT_C192641 subClassOf NCIT_C164001 @default.
- NCIT_C192641 subClassOf NCIT_C1742 @default.
- NCIT_C192641 subClassOf NCIT_C1908 @default.
- NCIT_C192641 subClassOf NCIT_C1909 @default.
- NCIT_C192641 subClassOf NCIT_C192641 @default.
- NCIT_C192641 subClassOf NCIT_C198860 @default.
- NCIT_C192641 subClassOf NCIT_C20401 @default.
- NCIT_C192641 subClassOf NCIT_C2496 @default.
- NCIT_C192641 subClassOf NCIT_C274 @default.
- NCIT_C192641 subClassOf NCIT_C307 @default.
- NCIT_C192641 subClassOf NCIT_C308 @default.