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- NCIT_C192642 IAO_0000115 "An immunoglobulin G1 (IgG1) monoclonal antibody directed against the human tumor-associated antigen (TAA) CD70, with potential immunomodulatory and antineoplastic activities. Upon administration, anti-CD70 monoclonal antibody IMM40H selectivity targets and binds to CD70, which blocks CD70-mediated signaling. This may inhibit cellular proliferation and survival of CD70-expressing tumor cells, and may modulate the immune system to inhibit inflammatory signals and increase antigen-specific T-cell responses in the tumor microenvironment (TME). In addition, IMM40H induces antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC) against CD70-expressing tumor cells. CD70, a member of the tumor necrosis factor (TNF) family, is aberrantly expressed on malignant myeloid blasts while absent from healthy hematopoietic progenitor cells." @default.
- NCIT_C192642 NCIT_A7 NCIT_C104079 @default.
- NCIT_C192642 NCIT_NHC0 "C192642" @default.
- NCIT_C192642 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C192642 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192642 NCIT_P108 "Anti-CD70 Monoclonal Antibody IMM40H" @default.
- NCIT_C192642 NCIT_P322 "GDC" @default.
- NCIT_C192642 NCIT_P399 "811454" @default.
- NCIT_C192642 NCIT_R124 NCIT_C17710 @default.
- NCIT_C192642 NCIT_R124 NCIT_C17828 @default.
- NCIT_C192642 NCIT_R124 NCIT_C18219 @default.
- NCIT_C192642 NCIT_R124 NCIT_C19986 @default.
- NCIT_C192642 NCIT_R124 NCIT_C40474 @default.
- NCIT_C192642 normalizedInformationContent "100" @default.
- NCIT_C192642 referenceCount "1" @default.
- NCIT_C192642 hasExactSynonym "Anti-CD70 Monoclonal Antibody IMM40H" @default.
- NCIT_C192642 hasExactSynonym "IMM 40H" @default.
- NCIT_C192642 hasExactSynonym "IMM-40H" @default.
- NCIT_C192642 hasExactSynonym "IMM40H" @default.
- NCIT_C192642 inSubset NCIT_C128784 @default.
- NCIT_C192642 inSubset NCIT_C157711 @default.
- NCIT_C192642 inSubset NCIT_C157712 @default.
- NCIT_C192642 inSubset NCIT_C176424 @default.
- NCIT_C192642 type Class @default.
- NCIT_C192642 isDefinedBy ncit.owl @default.
- NCIT_C192642 label "Anti-CD70 Monoclonal Antibody IMM40H" @default.
- NCIT_C192642 subClassOf NCIT_C129821 @default.
- NCIT_C192642 subClassOf NCIT_C129822 @default.
- NCIT_C192642 subClassOf NCIT_C163758 @default.
- NCIT_C192642 subClassOf NCIT_C1908 @default.
- NCIT_C192642 subClassOf NCIT_C1909 @default.
- NCIT_C192642 subClassOf NCIT_C192642 @default.
- NCIT_C192642 subClassOf NCIT_C192643 @default.
- NCIT_C192642 subClassOf NCIT_C200042 @default.
- NCIT_C192642 subClassOf NCIT_C20401 @default.
- NCIT_C192642 subClassOf NCIT_C274 @default.
- NCIT_C192642 subClassOf NCIT_C307 @default.
- NCIT_C192642 subClassOf NCIT_C308 @default.