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- NCIT_C192646 IAO_0000115 "A radioconjugate composed of pentixather, a chemokine receptor C-X-C chemokine receptor type 4 (CXCR4)-targeting ligand, conjugated to the alpha-emitting radioisotope lead Pb 212, with potential antineoplastic activity. Upon administration, lead Pb 212 pentixather targets and binds to CXCR4-expressing cancer cells. This allows for the specific delivery of a cytotoxic dose of alpha radiation to CXCR4-expressing cancer cells. CXCR4, a marker of poorly differentiated cells, is overexpressed on various cancer cells, and plays a key role in tumor growth, progression, invasiveness and metastasis." @default.
- NCIT_C192646 NCIT_A7 NCIT_C17789 @default.
- NCIT_C192646 NCIT_NHC0 "C192646" @default.
- NCIT_C192646 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192646 NCIT_P108 "Lead Pb 212 Pentixather" @default.
- NCIT_C192646 NCIT_P322 "GDC" @default.
- NCIT_C192646 NCIT_P399 "811457" @default.
- NCIT_C192646 normalizedInformationContent "100" @default.
- NCIT_C192646 referenceCount "1" @default.
- NCIT_C192646 hasExactSynonym "212-Lead Pentixather" @default.
- NCIT_C192646 hasExactSynonym "212Pb-Pentixather" @default.
- NCIT_C192646 hasExactSynonym "Lead 212-labeled Pentixather" @default.
- NCIT_C192646 hasExactSynonym "Lead Pb 212 Pentixather" @default.
- NCIT_C192646 hasExactSynonym "Lead Pb 212-Pentixather" @default.
- NCIT_C192646 inSubset NCIT_C128784 @default.
- NCIT_C192646 inSubset NCIT_C157711 @default.
- NCIT_C192646 inSubset NCIT_C157712 @default.
- NCIT_C192646 inSubset NCIT_C176424 @default.
- NCIT_C192646 type Class @default.
- NCIT_C192646 isDefinedBy ncit.owl @default.
- NCIT_C192646 label "Lead Pb 212 Pentixather" @default.
- NCIT_C192646 subClassOf NCIT_C129819 @default.
- NCIT_C192646 subClassOf NCIT_C1446 @default.
- NCIT_C192646 subClassOf NCIT_C1908 @default.
- NCIT_C192646 subClassOf NCIT_C1909 @default.
- NCIT_C192646 subClassOf NCIT_C192646 @default.
- NCIT_C192646 subClassOf NCIT_C200225 @default.
- NCIT_C192646 subClassOf NCIT_C2124 @default.
- NCIT_C192646 subClassOf NCIT_C274 @default.