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- NCIT_C192804 IAO_0000115 "An orally bioavailable selective inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral administration, CDK4/6 inhibitor SPH4336 selectively targets and inhibits the activity of CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase, prevents CDK-mediated G1-S-phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of both cell cycle progression from the G1-phase into the S-phase and tumor cell proliferation." @default.
- NCIT_C192804 NCIT_A7 NCIT_C17680 @default.
- NCIT_C192804 NCIT_A7 NCIT_C97386 @default.
- NCIT_C192804 NCIT_NHC0 "C192804" @default.
- NCIT_C192804 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C192804 NCIT_P108 "CDK4/6 Inhibitor SPH4336" @default.
- NCIT_C192804 NCIT_P322 "GDC" @default.
- NCIT_C192804 NCIT_P399 "811670" @default.
- NCIT_C192804 normalizedInformationContent "100" @default.
- NCIT_C192804 referenceCount "1" @default.
- NCIT_C192804 hasExactSynonym "CDK4/6 Inhibitor SPH4336" @default.
- NCIT_C192804 hasExactSynonym "SPH 4336" @default.
- NCIT_C192804 hasExactSynonym "SPH-4336" @default.
- NCIT_C192804 hasExactSynonym "SPH4336" @default.
- NCIT_C192804 inSubset NCIT_C128784 @default.
- NCIT_C192804 inSubset NCIT_C157711 @default.
- NCIT_C192804 inSubset NCIT_C157712 @default.
- NCIT_C192804 inSubset NCIT_C176424 @default.
- NCIT_C192804 type Class @default.
- NCIT_C192804 isDefinedBy ncit.owl @default.
- NCIT_C192804 label "CDK4/6 Inhibitor SPH4336" @default.
- NCIT_C192804 subClassOf NCIT_C129824 @default.
- NCIT_C192804 subClassOf NCIT_C129825 @default.
- NCIT_C192804 subClassOf NCIT_C1404 @default.
- NCIT_C192804 subClassOf NCIT_C163758 @default.
- NCIT_C192804 subClassOf NCIT_C1908 @default.
- NCIT_C192804 subClassOf NCIT_C1909 @default.
- NCIT_C192804 subClassOf NCIT_C192741 @default.
- NCIT_C192804 subClassOf NCIT_C192742 @default.
- NCIT_C192804 subClassOf NCIT_C192804 @default.
- NCIT_C192804 subClassOf NCIT_C2185 @default.
- NCIT_C192804 subClassOf NCIT_C2189 @default.
- NCIT_C192804 subClassOf NCIT_C274 @default.
- NCIT_C192804 subClassOf NCIT_C471 @default.
- NCIT_C192804 subClassOf NCIT_C61074 @default.