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- NCIT_C193460 IAO_0000115 "A tri-specific natural killer (NK) cell engager targeting epidermal growth factor receptor (EGFR), with potential immunostimulating and antineoplastic activities. Upon administration, EGFR tri-specific NK cell engager DF9001 targets and binds to EGFR on tumor cells and simultaneously binds to NK cells, thereby bringing EGFR-expressing tumor cells and NK cells together. This stimulates the NK cells and results in the selective NK cell-mediated killing of EGFR-expressing tumor cells. In addition, the NK cells activate T- and B-cells, and enhance a cytotoxic T-lymphocyte (CTL)-mediated immune response against EGFR-expressing tumor cells. EGFR, overexpressed by a variety of cancers, plays a key role in tumor cell proliferation and survival." @default.
- NCIT_C193460 NCIT_A7 NCIT_C17068 @default.
- NCIT_C193460 NCIT_NHC0 "C193460" @default.
- NCIT_C193460 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C193460 NCIT_P108 "EGFR Tri-specific Natural Killer Cell Engager DF9001" @default.
- NCIT_C193460 NCIT_P322 "GDC" @default.
- NCIT_C193460 NCIT_P399 "811740" @default.
- NCIT_C193460 normalizedInformationContent "100" @default.
- NCIT_C193460 referenceCount "1" @default.
- NCIT_C193460 hasExactSynonym "DF 9001" @default.
- NCIT_C193460 hasExactSynonym "DF-9001" @default.
- NCIT_C193460 hasExactSynonym "DF9001" @default.
- NCIT_C193460 hasExactSynonym "EGFR Tri-specific NK Cell Engager DF9001" @default.
- NCIT_C193460 hasExactSynonym "EGFR Tri-specific Natural Killer Cell Engager DF9001" @default.
- NCIT_C193460 hasExactSynonym "EGFR-targeting Tri-specific NK Cell Engager DF9001" @default.
- NCIT_C193460 hasExactSynonym "TriNKET DF9001" @default.
- NCIT_C193460 inSubset NCIT_C128784 @default.
- NCIT_C193460 inSubset NCIT_C157711 @default.
- NCIT_C193460 inSubset NCIT_C157712 @default.
- NCIT_C193460 inSubset NCIT_C176424 @default.
- NCIT_C193460 type Class @default.
- NCIT_C193460 isDefinedBy ncit.owl @default.
- NCIT_C193460 label "EGFR Tri-specific Natural Killer Cell Engager DF9001" @default.
- NCIT_C193460 subClassOf NCIT_C129820 @default.
- NCIT_C193460 subClassOf NCIT_C1908 @default.
- NCIT_C193460 subClassOf NCIT_C1909 @default.
- NCIT_C193460 subClassOf NCIT_C193460 @default.
- NCIT_C193460 subClassOf NCIT_C274 @default.
- NCIT_C193460 subClassOf NCIT_C308 @default.