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- NCIT_C193464 IAO_0000115 "The calcium salt form of AUR103, an orally bioavailable, small molecule antagonist of the human cell surface antigen CD47, with potential phagocytosis-inducing, immunostimulating and antineoplastic activities. Upon oral administration, CD47 antagonist AUR103 calcium binds to CD47 expressed on tumor cells and prevents the interaction of CD47 with its ligand SIRPa, a protein expressed on phagocytic cells. This prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated inhibition of phagocytosis. This induces pro-phagocytic signaling mediated by the binding of the pro-phagocytic signal calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein (LRP), expressed on macrophages. This results in macrophage activation and the specific phagocytosis of tumor cells. In addition, blocking CD47 signaling activates both an anti-tumor cytotoxic T-lymphocyte (CTL) immune response and T cell-mediated killing of CD47-expressing tumor cells. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSC) and overexpressed on the surface of a variety of cancer cells. Expression of CD47, and its interaction with SIRPa, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, which allows cancer cells to proliferate." @default.
- NCIT_C193464 NCIT_A7 NCIT_C25795 @default.
- NCIT_C193464 NCIT_NHC0 "C193464" @default.
- NCIT_C193464 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C193464 NCIT_P108 "CD47 Antagonist AUR103 Calcium" @default.
- NCIT_C193464 NCIT_P322 "GDC" @default.
- NCIT_C193464 NCIT_P399 "811749" @default.
- NCIT_C193464 normalizedInformationContent "100" @default.
- NCIT_C193464 referenceCount "1" @default.
- NCIT_C193464 hasExactSynonym "AUR 103 Calcium" @default.
- NCIT_C193464 hasExactSynonym "AUR-103 Calcium" @default.
- NCIT_C193464 hasExactSynonym "AUR103 Calcium" @default.
- NCIT_C193464 hasExactSynonym "CD47 Antagonist AUR103 Ca" @default.
- NCIT_C193464 hasExactSynonym "CD47 Antagonist AUR103 Calcium" @default.
- NCIT_C193464 inSubset NCIT_C128784 @default.
- NCIT_C193464 inSubset NCIT_C157711 @default.
- NCIT_C193464 inSubset NCIT_C157712 @default.
- NCIT_C193464 inSubset NCIT_C176424 @default.
- NCIT_C193464 type Class @default.
- NCIT_C193464 isDefinedBy ncit.owl @default.
- NCIT_C193464 label "CD47 Antagonist AUR103 Calcium" @default.
- NCIT_C193464 subClassOf NCIT_C129824 @default.
- NCIT_C193464 subClassOf NCIT_C163758 @default.
- NCIT_C193464 subClassOf NCIT_C1908 @default.
- NCIT_C193464 subClassOf NCIT_C1909 @default.
- NCIT_C193464 subClassOf NCIT_C192655 @default.
- NCIT_C193464 subClassOf NCIT_C193464 @default.
- NCIT_C193464 subClassOf NCIT_C2189 @default.
- NCIT_C193464 subClassOf NCIT_C274 @default.