Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C193471> ?p ?o ?g. }
Showing items 1 to 32 of
32
with 100 items per page.
- NCIT_C193471 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) conjugated via a cleavable linker to the camptothecin analog exatecan, with potential antineoplastic activity. Upon administration of the anti-TROP2 ADC BAT8008, the anti-TROP2 antibody targets and binds to TROP2 expressed on tumor cells. Upon binding, internalization and linker cleavage, exatecan is released. Exatecan inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation of TROP2-expressing tumor cells. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival." @default.
- NCIT_C193471 NCIT_A7 NCIT_C18544 @default.
- NCIT_C193471 NCIT_NHC0 "C193471" @default.
- NCIT_C193471 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C193471 NCIT_P108 "Anti-TROP2 Antibody-drug Conjugate BAT8008" @default.
- NCIT_C193471 NCIT_P322 "GDC" @default.
- NCIT_C193471 NCIT_P399 "811811" @default.
- NCIT_C193471 normalizedInformationContent "100" @default.
- NCIT_C193471 referenceCount "1" @default.
- NCIT_C193471 hasExactSynonym "Anti-TROP2 ADC BAT8008" @default.
- NCIT_C193471 hasExactSynonym "Anti-TROP2 Antibody-drug Conjugate BAT8008" @default.
- NCIT_C193471 hasExactSynonym "Anti-TROP2/Exatecan ADC BAT8008" @default.
- NCIT_C193471 hasExactSynonym "BAT 8008" @default.
- NCIT_C193471 hasExactSynonym "BAT-8008" @default.
- NCIT_C193471 hasExactSynonym "BAT8008" @default.
- NCIT_C193471 inSubset NCIT_C128784 @default.
- NCIT_C193471 inSubset NCIT_C157711 @default.
- NCIT_C193471 inSubset NCIT_C157712 @default.
- NCIT_C193471 inSubset NCIT_C176424 @default.
- NCIT_C193471 type Class @default.
- NCIT_C193471 isDefinedBy ncit.owl @default.
- NCIT_C193471 label "Anti-TROP2 Antibody-drug Conjugate BAT8008" @default.
- NCIT_C193471 subClassOf NCIT_C129821 @default.
- NCIT_C193471 subClassOf NCIT_C129823 @default.
- NCIT_C193471 subClassOf NCIT_C1512 @default.
- NCIT_C193471 subClassOf NCIT_C1908 @default.
- NCIT_C193471 subClassOf NCIT_C1909 @default.
- NCIT_C193471 subClassOf NCIT_C193471 @default.
- NCIT_C193471 subClassOf NCIT_C200106 @default.
- NCIT_C193471 subClassOf NCIT_C274 @default.
- NCIT_C193471 subClassOf NCIT_C307 @default.
- NCIT_C193471 subClassOf NCIT_C308 @default.