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- NCIT_C193472 IAO_0000115 "An attenuated oncolytic influenza A virus, with hemagglutinin and neuraminidase genes of influenza virus strain A/California/07/2009 codon-pair deoptimized, with potential oncolytic activity. Upon intratumoral administration, oncolytic influenza A virus selectively targets and replicates in cancer cells without being able to infect and replicate in normal, healthy cells. This induces selective oncolytic virus-mediated cytotoxicity in cancer cells, which leads to cancer cell lysis. Following the lysis of infected cells, the replicated virus is released and can infect adjacent tumor cells, which both induces further tumor cell oncolysis and may activate the immune system to exert an anti-tumor immune response against the tumor cells." @default.
- NCIT_C193472 NCIT_NHC0 "C193472" @default.
- NCIT_C193472 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C193472 NCIT_P106 "Virus" @default.
- NCIT_C193472 NCIT_P108 "Oncolytic Influenza A Virus" @default.
- NCIT_C193472 NCIT_P322 "GDC" @default.
- NCIT_C193472 NCIT_P399 "811813" @default.
- NCIT_C193472 normalizedInformationContent "100" @default.
- NCIT_C193472 referenceCount "1" @default.
- NCIT_C193472 hasExactSynonym "CodaLytic" @default.
- NCIT_C193472 hasExactSynonym "Oncolytic Influenza A Virus" @default.
- NCIT_C193472 inSubset NCIT_C128784 @default.
- NCIT_C193472 inSubset NCIT_C157711 @default.
- NCIT_C193472 inSubset NCIT_C157712 @default.
- NCIT_C193472 inSubset NCIT_C176424 @default.
- NCIT_C193472 type Class @default.
- NCIT_C193472 isDefinedBy ncit.owl @default.
- NCIT_C193472 label "Oncolytic Influenza A Virus" @default.
- NCIT_C193472 subClassOf NCIT_C129821 @default.
- NCIT_C193472 subClassOf NCIT_C1908 @default.
- NCIT_C193472 subClassOf NCIT_C1909 @default.
- NCIT_C193472 subClassOf NCIT_C193472 @default.
- NCIT_C193472 subClassOf NCIT_C274 @default.
- NCIT_C193472 subClassOf NCIT_C307 @default.
- NCIT_C193472 subClassOf NCIT_C717 @default.