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- NCIT_C193474 IAO_0000115 "A bispecific antibody directed against both the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-ROR1/anti-CD3 bispecific antibody EMB-07 binds to both ROR1 expressed on tumor cells and CD3 expressed on cytotoxic T-lymphocytes (CTLs). This activates and redirects CTLs to ROR1-expressing tumor cells, which results in the CTL-mediated death of ROR1-expressing tumor cells. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in many types of hematological malignancies. It plays key roles in tumor cell proliferation and survival." @default.
- NCIT_C193474 NCIT_A7 NCIT_C29879 @default.
- NCIT_C193474 NCIT_NHC0 "C193474" @default.
- NCIT_C193474 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C193474 NCIT_P108 "Anti-ROR1/Anti-CD3 Bispecific Antibody EMB-07" @default.
- NCIT_C193474 NCIT_P322 "GDC" @default.
- NCIT_C193474 NCIT_P399 "811816" @default.
- NCIT_C193474 NCIT_R124 NCIT_C17710 @default.
- NCIT_C193474 NCIT_R124 NCIT_C17828 @default.
- NCIT_C193474 NCIT_R124 NCIT_C18219 @default.
- NCIT_C193474 NCIT_R124 NCIT_C19986 @default.
- NCIT_C193474 NCIT_R124 NCIT_C40474 @default.
- NCIT_C193474 normalizedInformationContent "100" @default.
- NCIT_C193474 referenceCount "1" @default.
- NCIT_C193474 hasExactSynonym "Anti-ROR1/Anti-CD3 Bispecific Antibody EMB-07" @default.
- NCIT_C193474 hasExactSynonym "Anti-ROR1/CD3 Bispecific Antibody EMB-07" @default.
- NCIT_C193474 hasExactSynonym "EMB 07" @default.
- NCIT_C193474 hasExactSynonym "EMB-07" @default.
- NCIT_C193474 hasExactSynonym "EMB07" @default.
- NCIT_C193474 hasExactSynonym "ROR1 x CD3 Bispecific Antibody EMB-07" @default.
- NCIT_C193474 inSubset NCIT_C128784 @default.
- NCIT_C193474 inSubset NCIT_C157711 @default.
- NCIT_C193474 inSubset NCIT_C157712 @default.
- NCIT_C193474 inSubset NCIT_C176424 @default.
- NCIT_C193474 type Class @default.
- NCIT_C193474 isDefinedBy ncit.owl @default.
- NCIT_C193474 label "Anti-ROR1/Anti-CD3 Bispecific Antibody EMB-07" @default.
- NCIT_C193474 subClassOf NCIT_C112883 @default.
- NCIT_C193474 subClassOf NCIT_C129821 @default.
- NCIT_C193474 subClassOf NCIT_C129822 @default.
- NCIT_C193474 subClassOf NCIT_C1454 @default.
- NCIT_C193474 subClassOf NCIT_C163758 @default.
- NCIT_C193474 subClassOf NCIT_C1908 @default.
- NCIT_C193474 subClassOf NCIT_C1909 @default.
- NCIT_C193474 subClassOf NCIT_C193474 @default.
- NCIT_C193474 subClassOf NCIT_C199675 @default.
- NCIT_C193474 subClassOf NCIT_C201282 @default.
- NCIT_C193474 subClassOf NCIT_C20401 @default.
- NCIT_C193474 subClassOf NCIT_C274 @default.
- NCIT_C193474 subClassOf NCIT_C28227 @default.
- NCIT_C193474 subClassOf NCIT_C307 @default.
- NCIT_C193474 subClassOf NCIT_C308 @default.