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- NCIT_C19358 IAO_0000115 "Ubiquitin is a family of widely distributed proteins found in all eukaryotes that contain a highly conserved sequence of 76 amino acids identical in organisms from humans to insects. It participates in diverse cellular functions by conjugation to other proteins through its carboxy terminus. Ubiquitination is associated with many highly regulated biological events including protein degradation, chromatin remodelling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. Protein ubiquitination regulates the half-lives of many proteins by targeting them for degradation. Newly discovered families of ubiquitination and deubiquitination enzymes participate in these processes. Ubiquitination enzymes may provide new therapeutic targets and ways of intervention in many human diseases." @default.
- NCIT_C19358 NCIT_NHC0 "C19358" @default.
- NCIT_C19358 NCIT_P106 "Molecular Function" @default.
- NCIT_C19358 NCIT_P108 "Ubiquitination" @default.
- NCIT_C19358 NCIT_P207 "C1519751" @default.
- NCIT_C19358 NCIT_P366 "Ubiquitination" @default.
- NCIT_C19358 NCIT_R35 NCIT_C17710 @default.
- NCIT_C19358 NCIT_R35 NCIT_C17828 @default.
- NCIT_C19358 NCIT_R35 NCIT_C18104 @default.
- NCIT_C19358 NCIT_R35 NCIT_C19406 @default.
- NCIT_C19358 NCIT_R35 NCIT_C19536 @default.
- NCIT_C19358 NCIT_R35 NCIT_C19903 @default.
- NCIT_C19358 NCIT_R35 NCIT_C19986 @default.
- NCIT_C19358 NCIT_R35 NCIT_C21198 @default.
- NCIT_C19358 NCIT_R35 NCIT_C28498 @default.
- NCIT_C19358 NCIT_R35 NCIT_C61559 @default.
- NCIT_C19358 normalizedInformationContent "59.544773793988455" @default.
- NCIT_C19358 referenceCount "452" @default.
- NCIT_C19358 hasExactSynonym "Protein Ubiquitination" @default.
- NCIT_C19358 hasExactSynonym "Ubiquitilation" @default.
- NCIT_C19358 hasExactSynonym "Ubiquitination" @default.
- NCIT_C19358 hasExactSynonym "Ubiquitinoylation" @default.
- NCIT_C19358 hasExactSynonym "Ubiquitylation" @default.
- NCIT_C19358 type Class @default.
- NCIT_C19358 isDefinedBy ncit.owl @default.
- NCIT_C19358 label "Ubiquitination" @default.
- NCIT_C19358 subClassOf B40a873bad200b21ea12ca87921fd370e @default.
- NCIT_C19358 subClassOf B4d57439dc126c95cc78c0d46597d5f40 @default.
- NCIT_C19358 subClassOf NCIT_C17019 @default.
- NCIT_C19358 subClassOf NCIT_C17710 @default.
- NCIT_C19358 subClassOf NCIT_C17828 @default.
- NCIT_C19358 subClassOf NCIT_C19358 @default.
- NCIT_C19358 subClassOf NCIT_C19406 @default.
- NCIT_C19358 subClassOf NCIT_C19536 @default.
- NCIT_C19358 subClassOf NCIT_C19903 @default.
- NCIT_C19358 subClassOf NCIT_C21198 @default.
- NCIT_C19358 subClassOf NCIT_C28498 @default.