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- NCIT_C198007 IAO_0000115 "A therapeutic codon-optimized DNA vaccine encoding for the E6 and E7 proteins of human papillomavirus (HPV) subtypes 16 and 18, with potential immunostimulating and antineoplastic activities. Upon administration, the HPV 16/18 E6/E7 DNA vaccine pBI-11 expresses the HPV 16/18 E6/E7 fusion protein which may elicit a specific cytotoxic T-lymphocyte (CTL) response against cancer cells expressing the HPV 16/18 E6 and E7 oncoproteins, resulting in tumor cell lysis. HPV type 16 and 18 are the most common HPV types involved in cervical carcinogenesis. Codon optimization of the HPV16/18 E6/E7 genes in pBI-11 improves fusion protein expression." @default.
- NCIT_C198007 NCIT_A7 NCIT_C1179 @default.
- NCIT_C198007 NCIT_A7 NCIT_C1397 @default.
- NCIT_C198007 NCIT_NHC0 "C198007" @default.
- NCIT_C198007 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C198007 NCIT_P107 "HPV 16/18 E6/E7 DNA Vaccine pBI-11" @default.
- NCIT_C198007 NCIT_P108 "HPV 16/18 E6/E7 DNA Vaccine pBI-11" @default.
- NCIT_C198007 NCIT_P322 "CTRP" @default.
- NCIT_C198007 NCIT_P322 "GDC" @default.
- NCIT_C198007 NCIT_P399 "812075" @default.
- NCIT_C198007 normalizedInformationContent "100" @default.
- NCIT_C198007 referenceCount "1" @default.
- NCIT_C198007 hasExactSynonym "DNA Vaccine pBI-11" @default.
- NCIT_C198007 hasExactSynonym "E6/E7 DNA Vaccine pBI-11" @default.
- NCIT_C198007 hasExactSynonym "HPV 16/18 E6/E7 DNA Vaccine pBI-11" @default.
- NCIT_C198007 hasExactSynonym "pBI 11" @default.
- NCIT_C198007 hasExactSynonym "pBI-11" @default.
- NCIT_C198007 hasExactSynonym "pBI11" @default.
- NCIT_C198007 inSubset NCIT_C116977 @default.
- NCIT_C198007 inSubset NCIT_C116978 @default.
- NCIT_C198007 inSubset NCIT_C128784 @default.
- NCIT_C198007 inSubset NCIT_C157711 @default.
- NCIT_C198007 inSubset NCIT_C157712 @default.
- NCIT_C198007 inSubset NCIT_C176424 @default.
- NCIT_C198007 type Class @default.
- NCIT_C198007 isDefinedBy ncit.owl @default.
- NCIT_C198007 label "HPV 16/18 E6/E7 DNA Vaccine pBI-11" @default.
- NCIT_C198007 subClassOf NCIT_C129820 @default.
- NCIT_C198007 subClassOf NCIT_C1572 @default.
- NCIT_C198007 subClassOf NCIT_C1663 @default.
- NCIT_C198007 subClassOf NCIT_C1908 @default.
- NCIT_C198007 subClassOf NCIT_C1909 @default.
- NCIT_C198007 subClassOf NCIT_C198007 @default.
- NCIT_C198007 subClassOf NCIT_C274 @default.
- NCIT_C198007 subClassOf NCIT_C307 @default.
- NCIT_C198007 subClassOf NCIT_C308 @default.
- NCIT_C198007 subClassOf NCIT_C923 @default.
- NCIT_C198007 subClassOf NCIT_C96404 @default.