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- NCIT_C198220 IAO_0000115 "An orally bioavailable inhibitor of Bruton's tyrosine kinase (BTK; Bruton agammaglobulinemia tyrosine kinase), with potential antineoplastic activity. Upon oral administration, BTK inhibitor TQB3702 targets, binds to and inhibits the activity of BTK. This prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed or mutated in B-cell malignancies; it plays an important role in the development, activation, signaling, proliferation and survival of B-lymphocytes." @default.
- NCIT_C198220 NCIT_A7 NCIT_C75017 @default.
- NCIT_C198220 NCIT_NHC0 "C198220" @default.
- NCIT_C198220 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C198220 NCIT_P108 "BTK Inhibitor TQB3702" @default.
- NCIT_C198220 NCIT_P322 "GDC" @default.
- NCIT_C198220 NCIT_P399 "811943" @default.
- NCIT_C198220 normalizedInformationContent "100" @default.
- NCIT_C198220 referenceCount "1" @default.
- NCIT_C198220 hasExactSynonym "BTK Inhibitor TQB3702" @default.
- NCIT_C198220 hasExactSynonym "Bruton's Tyrosine Kinase Inhibitor TQB3702" @default.
- NCIT_C198220 hasExactSynonym "TQB 3702" @default.
- NCIT_C198220 hasExactSynonym "TQB-3702" @default.
- NCIT_C198220 hasExactSynonym "TQB3702" @default.
- NCIT_C198220 inSubset NCIT_C128784 @default.
- NCIT_C198220 inSubset NCIT_C157711 @default.
- NCIT_C198220 inSubset NCIT_C157712 @default.
- NCIT_C198220 inSubset NCIT_C176424 @default.
- NCIT_C198220 type Class @default.
- NCIT_C198220 isDefinedBy ncit.owl @default.
- NCIT_C198220 label "BTK Inhibitor TQB3702" @default.
- NCIT_C198220 subClassOf NCIT_C124801 @default.
- NCIT_C198220 subClassOf NCIT_C129824 @default.
- NCIT_C198220 subClassOf NCIT_C129825 @default.
- NCIT_C198220 subClassOf NCIT_C1404 @default.
- NCIT_C198220 subClassOf NCIT_C163758 @default.
- NCIT_C198220 subClassOf NCIT_C163774 @default.
- NCIT_C198220 subClassOf NCIT_C1908 @default.
- NCIT_C198220 subClassOf NCIT_C1909 @default.
- NCIT_C198220 subClassOf NCIT_C1967 @default.
- NCIT_C198220 subClassOf NCIT_C198220 @default.
- NCIT_C198220 subClassOf NCIT_C2189 @default.
- NCIT_C198220 subClassOf NCIT_C274 @default.
- NCIT_C198220 subClassOf NCIT_C471 @default.