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- NCIT_C198647 IAO_0000115 "A preparation of autologous activated T-lymphocytes that have been coated with a bispecific antibody comprised of an anti-CD3 monoclonal antibody heteroconjugated to an anti-signaling lymphocytic activation molecule family member 7 (SLAMF7; CD319; CRACC; CS-1) monoclonal antibody, with potential immunomodulating and antineoplastic activities. Upon administration, autologous anti-CD3/anti-SLAMF7 bispecific antibody-armed activated T-lymphocytes target and bind to both CD3 expressed on T-cells and SLAMF7 expressed on tumor cells, thereby cross-linking CD3-expressing T-cells and SLAMF7-expressing tumor cells. This results in the activation of cytotoxic T-lymphocytes (CTLs) and selective cytotoxicity towards SLAMF7-expressing tumor cells. In addition, cytokine and chemokine secretion by the T-cells further activates the immune system, which leads to the recruitment and activation of CTLs, and additional CTL-mediated tumor-specific cell lysis. SLAMF7 is a member of the signaling lymphocytic activation molecule (SLAM) family of transmembrane receptors that modulate the function of immune cells through immunoreceptor tyrosine-based switch motifs (ITSMs) and intracellular adaptor proteins. SLAMF7 is highly expressed on certain malignant plasma cells and is minimally expressed on healthy immune cells." @default.
- NCIT_C198647 NCIT_A7 NCIT_C95308 @default.
- NCIT_C198647 NCIT_NHC0 "C198647" @default.
- NCIT_C198647 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C198647 NCIT_P107 "Autologous Anti-CD3/Anti-SLAMF7 Bispecific Antibody-armed Activated T-lymphocytes" @default.
- NCIT_C198647 NCIT_P108 "Autologous Anti-CD3/Anti-SLAMF7 Bispecific Antibody-armed Activated T-lymphocytes" @default.
- NCIT_C198647 NCIT_P322 "CTRP" @default.
- NCIT_C198647 NCIT_P399 "812482" @default.
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- NCIT_C198647 normalizedInformationContent "100" @default.
- NCIT_C198647 referenceCount "1" @default.
- NCIT_C198647 hasExactSynonym "Autologous Anti-CD3 x Anti-SLAMF7 Bispecific Antibody Armed Activated T-cells" @default.
- NCIT_C198647 hasExactSynonym "Autologous Anti-CD3/Anti-CS-1 Bispecific Antibody-armed Activated T-lymphocytes" @default.
- NCIT_C198647 hasExactSynonym "Autologous Anti-CD3/Anti-SLAMF7 Bispecific Antibody-armed Activated T-lymphocytes" @default.
- NCIT_C198647 hasExactSynonym "CS-1 BATs" @default.
- NCIT_C198647 hasExactSynonym "SLAMF7 BATs" @default.
- NCIT_C198647 inSubset NCIT_C116977 @default.
- NCIT_C198647 inSubset NCIT_C116978 @default.
- NCIT_C198647 inSubset NCIT_C128784 @default.
- NCIT_C198647 inSubset NCIT_C176424 @default.
- NCIT_C198647 type Class @default.
- NCIT_C198647 isDefinedBy ncit.owl @default.
- NCIT_C198647 label "Autologous Anti-CD3/Anti-SLAMF7 Bispecific Antibody-armed Activated T-lymphocytes" @default.
- NCIT_C198647 subClassOf NCIT_C129820 @default.
- NCIT_C198647 subClassOf NCIT_C129821 @default.
- NCIT_C198647 subClassOf NCIT_C129826 @default.
- NCIT_C198647 subClassOf NCIT_C142078 @default.
- NCIT_C198647 subClassOf NCIT_C1908 @default.
- NCIT_C198647 subClassOf NCIT_C1909 @default.
- NCIT_C198647 subClassOf NCIT_C198647 @default.
- NCIT_C198647 subClassOf NCIT_C274 @default.
- NCIT_C198647 subClassOf NCIT_C28681 @default.
- NCIT_C198647 subClassOf NCIT_C307 @default.
- NCIT_C198647 subClassOf NCIT_C308 @default.