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- NCIT_C198686 IAO_0000115 "A recombinant fusion protein consisting of a human monoclonal antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4) fused to the immunostimulatory cytokine interleukin-15 (IL-15) cross-linked with the sushi domain of IL-15 receptor alpha (IL-15Ra), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration of anti-CTLA-4 monoclonal antibody-IL-15/IL-15Ra fusion protein JK08, the monoclonal antibody domain targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. The IL-15/IL-15Ra complex targets and binds to CD8+ T and natural killer (NK) cells, thereby increasing their activation and proliferation. Altogether, this leads to an inhibition of regulatory T-cell (Tregs)-mediated immunosuppression, induces antibody-dependent cellular cytotoxicity (ADCC), increases memory T-cells and enhances a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system." @default.
- NCIT_C198686 NCIT_A7 NCIT_C128303 @default.
- NCIT_C198686 NCIT_A7 NCIT_C17489 @default.
- NCIT_C198686 NCIT_NHC0 "C198686" @default.
- NCIT_C198686 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C198686 NCIT_P108 "Anti-CTLA-4 Monoclonal Antibody-IL-15/IL-15Ra Fusion Protein JK08" @default.
- NCIT_C198686 NCIT_P322 "GDC" @default.
- NCIT_C198686 NCIT_P399 "812053" @default.
- NCIT_C198686 normalizedInformationContent "100" @default.
- NCIT_C198686 referenceCount "1" @default.
- NCIT_C198686 hasExactSynonym "Anti-CTLA-4 Monoclonal Antibody-IL-15/IL-15Ra Fusion Protein JK08" @default.
- NCIT_C198686 hasExactSynonym "Fusion Protein JK08" @default.
- NCIT_C198686 hasExactSynonym "JK 08" @default.
- NCIT_C198686 hasExactSynonym "JK-08" @default.
- NCIT_C198686 hasExactSynonym "JK08" @default.
- NCIT_C198686 inSubset NCIT_C128784 @default.
- NCIT_C198686 inSubset NCIT_C157711 @default.
- NCIT_C198686 inSubset NCIT_C157712 @default.
- NCIT_C198686 inSubset NCIT_C176424 @default.
- NCIT_C198686 type Class @default.
- NCIT_C198686 isDefinedBy ncit.owl @default.
- NCIT_C198686 label "Anti-CTLA-4 Monoclonal Antibody-IL-15/IL-15Ra Fusion Protein JK08" @default.
- NCIT_C198686 subClassOf NCIT_C129821 @default.
- NCIT_C198686 subClassOf NCIT_C141144 @default.
- NCIT_C198686 subClassOf NCIT_C143250 @default.
- NCIT_C198686 subClassOf NCIT_C163758 @default.
- NCIT_C198686 subClassOf NCIT_C1908 @default.
- NCIT_C198686 subClassOf NCIT_C1909 @default.
- NCIT_C198686 subClassOf NCIT_C191738 @default.
- NCIT_C198686 subClassOf NCIT_C198686 @default.
- NCIT_C198686 subClassOf NCIT_C274 @default.
- NCIT_C198686 subClassOf NCIT_C307 @default.
- NCIT_C198686 subClassOf NCIT_C308 @default.