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- NCIT_C198688 IAO_0000115 "An orally bioavailable inhibitor of the receptor tyrosine kinases AXL (UFO) and FMS-like tyrosine kinase-3 (FLT3; CD135; fetal liver kinase-2; Flk2), with potential antineoplastic activity. Upon oral administration, AXL/FLT3 inhibitor TT-00973 binds to and inhibits AXL and FLT3, including the FLT3-ITD-F691L gatekeeper mutation. Inhibition of these kinases leads to the disruption of downstream signaling pathways and the inhibition of cell growth of tumors in which these kinases are overexpressed or mutated. AXL, a member of the Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases, is overexpressed by many tumor cell types and also expressed in a variety of immune cells including macrophages, natural killer (NK) cells, and regulatory T-cells (Tregs). It plays a key role in tumor cell proliferation, survival, invasion and metastasis, and is a mediator of immunosuppression. Its expression is associated with drug resistance and poor prognosis. FLT3, a class III tyrosine kinase receptor, is overexpressed or mutated in most B lineage and acute myeloid leukemias." @default.
- NCIT_C198688 NCIT_A7 NCIT_C17475 @default.
- NCIT_C198688 NCIT_A7 NCIT_C26202 @default.
- NCIT_C198688 NCIT_NHC0 "C198688" @default.
- NCIT_C198688 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C198688 NCIT_P108 "AXL/FLT3 Inhibitor TT-00973" @default.
- NCIT_C198688 NCIT_P322 "GDC" @default.
- NCIT_C198688 NCIT_P399 "812055" @default.
- NCIT_C198688 normalizedInformationContent "100" @default.
- NCIT_C198688 referenceCount "1" @default.
- NCIT_C198688 hasExactSynonym "AXL/FLT3 Inhibitor TT-00973" @default.
- NCIT_C198688 hasExactSynonym "TT 00973" @default.
- NCIT_C198688 hasExactSynonym "TT-00973" @default.
- NCIT_C198688 hasExactSynonym "TT00973" @default.
- NCIT_C198688 inSubset NCIT_C128784 @default.
- NCIT_C198688 inSubset NCIT_C157711 @default.
- NCIT_C198688 inSubset NCIT_C157712 @default.
- NCIT_C198688 inSubset NCIT_C176424 @default.
- NCIT_C198688 type Class @default.
- NCIT_C198688 isDefinedBy ncit.owl @default.
- NCIT_C198688 label "AXL/FLT3 Inhibitor TT-00973" @default.
- NCIT_C198688 subClassOf NCIT_C124800 @default.
- NCIT_C198688 subClassOf NCIT_C129824 @default.
- NCIT_C198688 subClassOf NCIT_C129825 @default.
- NCIT_C198688 subClassOf NCIT_C1404 @default.
- NCIT_C198688 subClassOf NCIT_C163758 @default.
- NCIT_C198688 subClassOf NCIT_C163790 @default.
- NCIT_C198688 subClassOf NCIT_C1908 @default.
- NCIT_C198688 subClassOf NCIT_C1909 @default.
- NCIT_C198688 subClassOf NCIT_C1967 @default.
- NCIT_C198688 subClassOf NCIT_C198688 @default.
- NCIT_C198688 subClassOf NCIT_C200418 @default.
- NCIT_C198688 subClassOf NCIT_C2189 @default.
- NCIT_C198688 subClassOf NCIT_C274 @default.
- NCIT_C198688 subClassOf NCIT_C471 @default.