Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C198698> ?p ?o ?g. }
Showing items 1 to 31 of
31
with 100 items per page.
- NCIT_C198698 IAO_0000115 "A fusion protein composed of a recombinant humanized anti-Claudin18.2 (CLDN18.2; A2 isoform of claudin-18) heavy chain antibody (VHH) fused to an engineered immunoglobulin gamma-1 (IgG1) Fc fragment, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 heavy chain antibody Fc fusion protein DR30303 specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells. The binding induces antibody-dependent cellular cytotoxicity (ADCC) and may kill CLDN18.2-expressing tumor cells and inhibit tumor cell proliferation. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is overexpressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.
- NCIT_C198698 NCIT_A7 NCIT_C150412 @default.
- NCIT_C198698 NCIT_NHC0 "C198698" @default.
- NCIT_C198698 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C198698 NCIT_P108 "Anti-CLDN18.2 Heavy Chain Antibody Fc Fusion Protein DR30303" @default.
- NCIT_C198698 NCIT_P322 "GDC" @default.
- NCIT_C198698 NCIT_P399 "812098" @default.
- NCIT_C198698 normalizedInformationContent "100" @default.
- NCIT_C198698 referenceCount "1" @default.
- NCIT_C198698 hasExactSynonym "Anti-CLDN18.2 Heavy Chain Antibody Fc Fusion Protein DR30303" @default.
- NCIT_C198698 hasExactSynonym "Anti-CLDN18.2 VHH-Fc DR30303" @default.
- NCIT_C198698 hasExactSynonym "DR 30303" @default.
- NCIT_C198698 hasExactSynonym "DR-30303" @default.
- NCIT_C198698 hasExactSynonym "DR30303" @default.
- NCIT_C198698 hasExactSynonym "Fusion Protein DR30303" @default.
- NCIT_C198698 hasExactSynonym "VHH-Fc DR30303" @default.
- NCIT_C198698 inSubset NCIT_C128784 @default.
- NCIT_C198698 inSubset NCIT_C157711 @default.
- NCIT_C198698 inSubset NCIT_C157712 @default.
- NCIT_C198698 inSubset NCIT_C176424 @default.
- NCIT_C198698 type Class @default.
- NCIT_C198698 isDefinedBy ncit.owl @default.
- NCIT_C198698 label "Anti-CLDN18.2 Heavy Chain Antibody Fc Fusion Protein DR30303" @default.
- NCIT_C198698 subClassOf NCIT_C129820 @default.
- NCIT_C198698 subClassOf NCIT_C163758 @default.
- NCIT_C198698 subClassOf NCIT_C1908 @default.
- NCIT_C198698 subClassOf NCIT_C1909 @default.
- NCIT_C198698 subClassOf NCIT_C198698 @default.
- NCIT_C198698 subClassOf NCIT_C200250 @default.
- NCIT_C198698 subClassOf NCIT_C274 @default.
- NCIT_C198698 subClassOf NCIT_C308 @default.