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- NCIT_C19885 IAO_0000115 "Important in eukaryotic gene regulation, histone acetylation and deacetylation are catalyzed by histone deacetylase complexes that include SAP30, SAP18, histone deacetylases, histone-binding proteins and other proteins. SAP18 interacts with SIN3 and enhances SIN3-mediated transcriptional repression. Gene-specific targeting of the SIN3 co-repressor complex by DNA-bound repressors is important in eukaryotic gene silencing. The SIN3 co-repressor specifically associates with some transcriptional repressors, including members of the MAD family important in development. The PAH2 domain of SIN3A interacts with the transrepression domain (SID) of MAD1. MAD-MAX complexes repress transcription through recruitment of SIN3 co-repressor. The MXI1 protein family functions as potent antagonists of MYC oncoproteins. They compete with MYC for the protein MAX and for consensus DNA binding sites and to recruit SIN3 proteins and their associated co-repressors. (NCI)" @default.
- NCIT_C19885 NCIT_NHC0 "C19885" @default.
- NCIT_C19885 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C19885 NCIT_P108 "mSin3" @default.
- NCIT_C19885 NCIT_P207 "C1337051" @default.
- NCIT_C19885 NCIT_P366 "mSin3" @default.
- NCIT_C19885 NCIT_R45 NCIT_C14182 @default.
- NCIT_C19885 NCIT_R45 NCIT_C14234 @default.
- NCIT_C19885 NCIT_R45 NCIT_C14238 @default.
- NCIT_C19885 NCIT_R45 NCIT_C14246 @default.
- NCIT_C19885 NCIT_R45 NCIT_C14250 @default.
- NCIT_C19885 NCIT_R45 NCIT_C14270 @default.
- NCIT_C19885 NCIT_R45 NCIT_C14282 @default.
- NCIT_C19885 NCIT_R45 NCIT_C25796 @default.
- NCIT_C19885 normalizedInformationContent "100" @default.
- NCIT_C19885 referenceCount "1" @default.
- NCIT_C19885 hasExactSynonym "Mammalian Sin3" @default.
- NCIT_C19885 hasExactSynonym "mSin3" @default.
- NCIT_C19885 type Class @default.
- NCIT_C19885 isDefinedBy ncit.owl @default.
- NCIT_C19885 label "mSin3" @default.
- NCIT_C19885 subClassOf NCIT_C17021 @default.
- NCIT_C19885 subClassOf NCIT_C19885 @default.
- NCIT_C19885 subClassOf NCIT_C20032 @default.
- NCIT_C19885 subClassOf NCIT_C20158 @default.
- NCIT_C19885 subClassOf NCIT_C26532 @default.
- NCIT_C19885 subClassOf NCIT_C26548 @default.