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- NCIT_C19893 IAO_0000115 "MAD and MXI1 bZIP proteins belong to a subfamily of MAX-interacting proteins. MAX interacts with MYC via bZIP interaction domains and MAX binding is essential for MYC activity; MYC homodimers are inactive. MAD/MAX and MXI1/MAX heterodimers form a DNA-binding complex similar to MYC/MAX. MAD and MXI1 act as transcriptional repressors and appear to antagonize MYC by competing for MAX, and for DNA binding sites, and recruit SIN3 proteins and their associated co-repressors. (from OMIM 600021, 600020, and NCI)" @default.
- NCIT_C19893 NCIT_NHC0 "C19893" @default.
- NCIT_C19893 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C19893 NCIT_P108 "MAD/MXI1" @default.
- NCIT_C19893 NCIT_P200 "Transcription Corepressor" @default.
- NCIT_C19893 NCIT_P203 "Protein_Kind" @default.
- NCIT_C19893 NCIT_P310 "Retired_Concept" @default.
- NCIT_C19893 NCIT_P98 "See 'MAX Interacting Protein 1' or 'MAX Dimerization Protein 1'" @default.
- NCIT_C19893 normalizedInformationContent "100" @default.
- NCIT_C19893 referenceCount "1" @default.
- NCIT_C19893 hasExactSynonym "MAD/MXI1" @default.
- NCIT_C19893 type Class @default.
- NCIT_C19893 isDefinedBy ncit.owl @default.
- NCIT_C19893 label "MAD/MXI1" @default.
- NCIT_C19893 subClassOf NCIT_C19893 @default.
- NCIT_C19893 subClassOf NCIT_C28428 @default.
- NCIT_C19893 subClassOf NCIT_C83479 @default.
- NCIT_C19893 deprecated "true" @default.