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- NCIT_C198978 IAO_0000115 "The besylate salt form of the R-enantiomer of azasetron, a benzamide derivative and selective serotonin (5-hydroxytryptamine; 5-HT) receptor and calcineurin antagonist, with potential antinauseant and antiemetic, and otoprotective activities. Upon administration, arazasetron selectively binds to and inhibits 5-HT subtype 3 receptors (5-HT3R) located peripherally on vagus nerve terminals and centrally in the chemoreceptor trigger zone (CTZ) of the area postrema, which may result in suppression of nausea and vomiting. R-azasetron also targets and inhibits the activation of calcineurin, thereby preventing inner ear lesions, nerve degeneration, induction of apoptosis and sensory hair loss. This may prevent hearing loss. Calcineurin activation plays a key role in structural degeneration, swelling, synaptic uncoupling and the induction of apoptosis in the inner ear leading to hair cell loss and hearing loss." @default.
- NCIT_C198978 NCIT_NHC0 "C198978" @default.
- NCIT_C198978 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C198978 NCIT_P108 "Arazasetron Besylate" @default.
- NCIT_C198978 NCIT_P210 "2025360-91-0" @default.
- NCIT_C198978 NCIT_P319 "UXP39EQ477" @default.
- NCIT_C198978 NCIT_P322 "FDA" @default.
- NCIT_C198978 NCIT_P399 "812138" @default.
- NCIT_C198978 normalizedInformationContent "100" @default.
- NCIT_C198978 referenceCount "1" @default.
- NCIT_C198978 hasExactSynonym "ARAZASETRON BESYLATE" @default.
- NCIT_C198978 hasExactSynonym "Arazasetron Besylate" @default.
- NCIT_C198978 hasExactSynonym "R-azasetron Besylate" @default.
- NCIT_C198978 hasExactSynonym "SENS 401" @default.
- NCIT_C198978 hasExactSynonym "SENS-401" @default.
- NCIT_C198978 hasExactSynonym "SENS401" @default.
- NCIT_C198978 inSubset NCIT_C176424 @default.
- NCIT_C198978 inSubset NCIT_C63923 @default.
- NCIT_C198978 type Class @default.
- NCIT_C198978 isDefinedBy ncit.owl @default.
- NCIT_C198978 label "Arazasetron Besylate" @default.
- NCIT_C198978 subClassOf NCIT_C1908 @default.
- NCIT_C198978 subClassOf NCIT_C1909 @default.
- NCIT_C198978 subClassOf NCIT_C198978 @default.
- NCIT_C198978 subClassOf NCIT_C66885 @default.
- NCIT_C198978 subClassOf NCIT_C78272 @default.
- NCIT_C198978 subClassOf NCIT_C94726 @default.