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- NCIT_C199227 IAO_0000115 "An orally bioavailable combination agent containing the prodrug bempedoic acid, an inhibitor of adenosine triphosphate-citrate lyase (ACL) and ezetimibe, a cholesterol absorption inhibitor, with lipid-lowering activity. Upon oral administration of bempedoic acid/ezetimibe, ezetimibe binds to the sterol transporter Niemann-Pick C1-Like 1 (NPC1L1) at the brush border of the small intestine and inhibits the intestinal absorption of biliary and dietary cholesterol and related phytosterols. This decreases blood cholesterol levels, decreases the delivery of intestinal cholesterol to the liver, reduces hepatic cholesterol stores and enhances the clearance of cholesterol from the bloodstream. Bempedoic acid is activated to its thioester form with coenzyme A (CoA) by the enzyme very long-chain acyl-CoA synthetase 1 (ACSVL1; SLC27A2) in the liver and inhibits ACL, thereby preventing the liver's biosynthesis of cholesterol. This lowers low-density lipoprotein cholesterol (LDL-C) levels. ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway." @default.
- NCIT_C199227 NCIT_NHC0 "C199227" @default.
- NCIT_C199227 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199227 NCIT_P108 "Bempedoic Acid/Ezetimibe" @default.
- NCIT_C199227 normalizedInformationContent "100" @default.
- NCIT_C199227 referenceCount "1" @default.
- NCIT_C199227 hasExactSynonym "Bempedoic Acid/Ezetimibe" @default.
- NCIT_C199227 hasExactSynonym "Nexlizet" @default.
- NCIT_C199227 type Class @default.
- NCIT_C199227 isDefinedBy ncit.owl @default.
- NCIT_C199227 label "Bempedoic Acid/Ezetimibe" @default.
- NCIT_C199227 subClassOf NCIT_C1908 @default.
- NCIT_C199227 subClassOf NCIT_C1909 @default.
- NCIT_C199227 subClassOf NCIT_C199227 @default.
- NCIT_C199227 subClassOf NCIT_C29703 @default.
- NCIT_C199227 subClassOf NCIT_C78276 @default.