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- NCIT_C199292 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) conjugated to an as of yet undisclosed topoisomerase inhibitor (TopoI), with potential antineoplastic activity. Upon administration of the anti-TROP-2/TopoI ADC MHB036C, the anti-TROP-2 antibody targets and binds to TROP-2 expressed on tumor cells. Upon binding, internalization and cleavage, TopoI is released, and inhibits DNA topoisomerase activity, thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation of TROP-2-expressing tumor cells. TROP-2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival." @default.
- NCIT_C199292 NCIT_A7 NCIT_C18544 @default.
- NCIT_C199292 NCIT_NHC0 "C199292" @default.
- NCIT_C199292 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199292 NCIT_P108 "Anti-TROP-2/Topoisomerase Inhibitor ADC MHB036C" @default.
- NCIT_C199292 NCIT_P322 "GDC" @default.
- NCIT_C199292 NCIT_P399 "812318" @default.
- NCIT_C199292 normalizedInformationContent "100" @default.
- NCIT_C199292 referenceCount "1" @default.
- NCIT_C199292 hasExactSynonym "ADC MHB036C" @default.
- NCIT_C199292 hasExactSynonym "Anti-TROP-2/TopoI ADC MHB036C" @default.
- NCIT_C199292 hasExactSynonym "Anti-TROP-2/Topoisomerase Inhibitor ADC MHB036C" @default.
- NCIT_C199292 hasExactSynonym "Antibody-drug Conjugate MHB036C" @default.
- NCIT_C199292 hasExactSynonym "MHB 036C" @default.
- NCIT_C199292 hasExactSynonym "MHB-036C" @default.
- NCIT_C199292 hasExactSynonym "MHB036C" @default.
- NCIT_C199292 hasExactSynonym "ZG 157" @default.
- NCIT_C199292 hasExactSynonym "ZG-157" @default.
- NCIT_C199292 hasExactSynonym "ZG157" @default.
- NCIT_C199292 inSubset NCIT_C128784 @default.
- NCIT_C199292 inSubset NCIT_C157711 @default.
- NCIT_C199292 inSubset NCIT_C157712 @default.
- NCIT_C199292 inSubset NCIT_C176424 @default.
- NCIT_C199292 type Class @default.
- NCIT_C199292 isDefinedBy ncit.owl @default.
- NCIT_C199292 label "Anti-TROP-2/Topoisomerase Inhibitor ADC MHB036C" @default.
- NCIT_C199292 subClassOf NCIT_C129821 @default.
- NCIT_C199292 subClassOf NCIT_C129823 @default.
- NCIT_C199292 subClassOf NCIT_C1512 @default.
- NCIT_C199292 subClassOf NCIT_C1908 @default.
- NCIT_C199292 subClassOf NCIT_C1909 @default.
- NCIT_C199292 subClassOf NCIT_C199292 @default.
- NCIT_C199292 subClassOf NCIT_C200106 @default.
- NCIT_C199292 subClassOf NCIT_C274 @default.
- NCIT_C199292 subClassOf NCIT_C307 @default.
- NCIT_C199292 subClassOf NCIT_C308 @default.