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- NCIT_C199306 IAO_0000115 "A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigens (TAAs) C-type-lectin-like molecule-1 (CLL-1; CLL1; C-type lectin domain family 12 member A; CLEC12A) and CD33, with potential immunomodulating and antineoplastic activities. Upon administration, the anti-CLL1/anti-CD33 CAR-T cells LCAR-AMDR specifically and simultaneously target and bind to CD33- and CLL1-expressing tumor cells. This induces selective toxicity in CD33- and CLL1-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells. CLL1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies." @default.
- NCIT_C199306 NCIT_A7 NCIT_C162378 @default.
- NCIT_C199306 NCIT_A7 NCIT_C97246 @default.
- NCIT_C199306 NCIT_NHC0 "C199306" @default.
- NCIT_C199306 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199306 NCIT_P108 "Anti-CLL1/Anti-CD33 CAR-T Cells LCAR-AMDR" @default.
- NCIT_C199306 NCIT_P322 "GDC" @default.
- NCIT_C199306 NCIT_P399 "812431" @default.
- NCIT_C199306 normalizedInformationContent "100" @default.
- NCIT_C199306 referenceCount "1" @default.
- NCIT_C199306 hasExactSynonym "Anti-CLL1/Anti-CD33 CAR-T Cells LCAR-AMDR" @default.
- NCIT_C199306 hasExactSynonym "Anti-CLL1/CD33 CAR T-cells LCAR-AMDR" @default.
- NCIT_C199306 hasExactSynonym "CLL-1/CD33-targeted CAR T Cells LCAR-AMDR" @default.
- NCIT_C199306 hasExactSynonym "LCAR-AMDR" @default.
- NCIT_C199306 inSubset NCIT_C128784 @default.
- NCIT_C199306 inSubset NCIT_C157711 @default.
- NCIT_C199306 inSubset NCIT_C157712 @default.
- NCIT_C199306 inSubset NCIT_C176424 @default.
- NCIT_C199306 type Class @default.
- NCIT_C199306 isDefinedBy ncit.owl @default.
- NCIT_C199306 label "Anti-CLL1/Anti-CD33 CAR-T Cells LCAR-AMDR" @default.
- NCIT_C199306 subClassOf NCIT_C129820 @default.
- NCIT_C199306 subClassOf NCIT_C129821 @default.
- NCIT_C199306 subClassOf NCIT_C129826 @default.
- NCIT_C199306 subClassOf NCIT_C137999 @default.
- NCIT_C199306 subClassOf NCIT_C142078 @default.
- NCIT_C199306 subClassOf NCIT_C154231 @default.
- NCIT_C199306 subClassOf NCIT_C1908 @default.
- NCIT_C199306 subClassOf NCIT_C1909 @default.
- NCIT_C199306 subClassOf NCIT_C1962 @default.
- NCIT_C199306 subClassOf NCIT_C199306 @default.
- NCIT_C199306 subClassOf NCIT_C201495 @default.
- NCIT_C199306 subClassOf NCIT_C274 @default.
- NCIT_C199306 subClassOf NCIT_C307 @default.
- NCIT_C199306 subClassOf NCIT_C308 @default.