Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C199307> ?p ?o ?g. }
Showing items 1 to 32 of
32
with 100 items per page.
- NCIT_C199307 IAO_0000115 "An orally bioavailable, selective, second-generation inhibitor of the proto-oncogene receptor tyrosine kinase rearranged during transfection (RET), with potential antineoplastic activity. Upon oral administration, RET inhibitor TY-1091 selectively targets and binds to wild-type RET and various RET fusions and mutations, including, but not limited to solvent front and gatekeeper mutations RET G810S, RET V804M/L/E, RET V804M/G810S and M918T/G810S, thereby inhibiting the activity of RET. This results in an inhibition of cell growth of tumors that exhibit increased RET activity due to these fusions and mutations. RET overexpression, activating mutations, and fusions result in the upregulation and/or overactivation of RET tyrosine kinase activity in various cancer cell types. Dysregulated RET activity plays a key role in the development and progression of certain cancers. Solvent front and gatekeeper resistance mutations play a key role in acquired tumor resistance to RET inhibitors." @default.
- NCIT_C199307 NCIT_A7 NCIT_C18539 @default.
- NCIT_C199307 NCIT_NHC0 "C199307" @default.
- NCIT_C199307 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199307 NCIT_P108 "RET Inhibitor TY-1091" @default.
- NCIT_C199307 NCIT_P322 "GDC" @default.
- NCIT_C199307 NCIT_P399 "812450" @default.
- NCIT_C199307 normalizedInformationContent "100" @default.
- NCIT_C199307 referenceCount "1" @default.
- NCIT_C199307 hasExactSynonym "RET Inhibitor TY-1091" @default.
- NCIT_C199307 hasExactSynonym "TY 1091" @default.
- NCIT_C199307 hasExactSynonym "TY-1091" @default.
- NCIT_C199307 hasExactSynonym "TY1091" @default.
- NCIT_C199307 inSubset NCIT_C128784 @default.
- NCIT_C199307 inSubset NCIT_C157711 @default.
- NCIT_C199307 inSubset NCIT_C157712 @default.
- NCIT_C199307 inSubset NCIT_C176424 @default.
- NCIT_C199307 type Class @default.
- NCIT_C199307 isDefinedBy ncit.owl @default.
- NCIT_C199307 label "RET Inhibitor TY-1091" @default.
- NCIT_C199307 subClassOf NCIT_C129824 @default.
- NCIT_C199307 subClassOf NCIT_C129825 @default.
- NCIT_C199307 subClassOf NCIT_C1404 @default.
- NCIT_C199307 subClassOf NCIT_C159438 @default.
- NCIT_C199307 subClassOf NCIT_C163758 @default.
- NCIT_C199307 subClassOf NCIT_C1908 @default.
- NCIT_C199307 subClassOf NCIT_C1909 @default.
- NCIT_C199307 subClassOf NCIT_C1967 @default.
- NCIT_C199307 subClassOf NCIT_C199307 @default.
- NCIT_C199307 subClassOf NCIT_C2189 @default.
- NCIT_C199307 subClassOf NCIT_C274 @default.
- NCIT_C199307 subClassOf NCIT_C471 @default.