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- NCIT_C199313 IAO_0000115 "A T-cell engaging, human, bispecific, immunoglobulin G1 (IgG1) monoclonal antibody directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD3/anti-BCMA bispecific antibody TQB2934 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA found on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated cell death of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival." @default.
- NCIT_C199313 NCIT_A7 NCIT_C97848 @default.
- NCIT_C199313 NCIT_NHC0 "C199313" @default.
- NCIT_C199313 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199313 NCIT_P108 "Anti-CD3/Anti-BCMA Bispecific Antibody TQB2934" @default.
- NCIT_C199313 NCIT_P322 "GDC" @default.
- NCIT_C199313 NCIT_P399 "812373" @default.
- NCIT_C199313 NCIT_R124 NCIT_C17710 @default.
- NCIT_C199313 NCIT_R124 NCIT_C17828 @default.
- NCIT_C199313 NCIT_R124 NCIT_C18219 @default.
- NCIT_C199313 NCIT_R124 NCIT_C19986 @default.
- NCIT_C199313 NCIT_R124 NCIT_C40474 @default.
- NCIT_C199313 normalizedInformationContent "100" @default.
- NCIT_C199313 referenceCount "1" @default.
- NCIT_C199313 hasExactSynonym "Anti-BCMA/Anti-CD3 Bispecific Antibody TQB2934" @default.
- NCIT_C199313 hasExactSynonym "Anti-CD3 x BCMA Double-specific Antibody TQB2934" @default.
- NCIT_C199313 hasExactSynonym "Anti-CD3/Anti-BCMA Bispecific Antibody TQB2934" @default.
- NCIT_C199313 hasExactSynonym "Anti-CD3/Anti-BCMA T-cell Engaging Bispecific Antibody TQB2934" @default.
- NCIT_C199313 hasExactSynonym "Anti-CD3/BCMA Bispecific Antibody TQB2934" @default.
- NCIT_C199313 hasExactSynonym "Bispecific Antibody TQB2934" @default.
- NCIT_C199313 hasExactSynonym "TQB 2934" @default.
- NCIT_C199313 hasExactSynonym "TQB-2934" @default.
- NCIT_C199313 hasExactSynonym "TQB2934" @default.
- NCIT_C199313 inSubset NCIT_C128784 @default.
- NCIT_C199313 inSubset NCIT_C157711 @default.
- NCIT_C199313 inSubset NCIT_C157712 @default.
- NCIT_C199313 inSubset NCIT_C176424 @default.
- NCIT_C199313 type Class @default.
- NCIT_C199313 isDefinedBy ncit.owl @default.
- NCIT_C199313 label "Anti-CD3/Anti-BCMA Bispecific Antibody TQB2934" @default.
- NCIT_C199313 subClassOf NCIT_C112883 @default.
- NCIT_C199313 subClassOf NCIT_C129821 @default.
- NCIT_C199313 subClassOf NCIT_C129822 @default.
- NCIT_C199313 subClassOf NCIT_C1454 @default.
- NCIT_C199313 subClassOf NCIT_C163758 @default.
- NCIT_C199313 subClassOf NCIT_C181111 @default.
- NCIT_C199313 subClassOf NCIT_C181113 @default.
- NCIT_C199313 subClassOf NCIT_C181114 @default.
- NCIT_C199313 subClassOf NCIT_C1908 @default.
- NCIT_C199313 subClassOf NCIT_C1909 @default.
- NCIT_C199313 subClassOf NCIT_C199313 @default.
- NCIT_C199313 subClassOf NCIT_C201282 @default.
- NCIT_C199313 subClassOf NCIT_C20401 @default.
- NCIT_C199313 subClassOf NCIT_C274 @default.
- NCIT_C199313 subClassOf NCIT_C28227 @default.
- NCIT_C199313 subClassOf NCIT_C307 @default.
- NCIT_C199313 subClassOf NCIT_C308 @default.