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- NCIT_C19934 IAO_0000115 "Non-histone chromosomal protein HMG-14 (100 aa, ~11 kDa) is encoded by the human HMGN1 gene. This protein plays a role in the regulation of DNA/histone interactions." @default.
- NCIT_C19934 NCIT_NHC0 "C19934" @default.
- NCIT_C19934 NCIT_P100 "163920" @default.
- NCIT_C19934 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C19934 NCIT_P106 "Biologically Active Substance" @default.
- NCIT_C19934 NCIT_P108 "Non-Histone Chromosomal Protein HMG-14" @default.
- NCIT_C19934 NCIT_P207 "C0019797" @default.
- NCIT_C19934 NCIT_P366 "HMGN1" @default.
- NCIT_C19934 NCIT_P93 "P05114" @default.
- NCIT_C19934 NCIT_P98 "Non-histone chromosomal protein known to specifically associate with the nucleosome core. This protein unfolds the higher order chromatin structure thereby facilitating access to the underlying DNA sequence and facilitating the orderly progression of various DNA-dependent activities in the context of chromatin. The protein actively shuttles between the nucleus and the cytoplasm, in a cell-cycle dependent manner. (NCI IRP summary) HMGN1 enhances the transcriptional potential of chromatin when incorporated into nucleosomes during, but not after, chromatin assembly on replicating DNA. Two molecules of HMGN1 can bind to nucleosome cores, independently of the underlying DNA sequence, in a cooperative fashion to limit nucleosome mobility and stabilize the structure of the nucleosome core without stabilizing the higher order chromatin structure. By modifying the structure of nucleosomes, the proteins affect the local structure of the chromatin fiber leading to an increase in the rate of transcriptional elongation but not initiation. (Semin Cell Biol 1995; 6:247-55.)" @default.
- NCIT_C19934 NCIT_P98 "Non-histone chromosomal protein known to specifically associate with the nucleosome core. This protein unfolds the higher order chromatin structure thereby facilitating access to the underlying DNA sequence and facilitating the orderly progression of various DNA-dependent activities in the context of chromatin. The protein actively shuttles between the nucleus and the cytoplasm, in a cell-cycle dependent manner. (NCI IRP summary)" @default.
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- NCIT_C19934 normalizedInformationContent "100" @default.
- NCIT_C19934 referenceCount "1" @default.
- NCIT_C19934 hasExactSynonym "Chromosomal Protein, Nonhistone, HMG14" @default.
- NCIT_C19934 hasExactSynonym "HMG 14" @default.
- NCIT_C19934 hasExactSynonym "HMG-14" @default.
- NCIT_C19934 hasExactSynonym "HMG14" @default.
- NCIT_C19934 hasExactSynonym "HMGN1 Protein" @default.
- NCIT_C19934 hasExactSynonym "HMGN1" @default.
- NCIT_C19934 hasExactSynonym "High Mobility Group Nucleosomal Binding Protein 1" @default.
- NCIT_C19934 hasExactSynonym "High Mobility Group Nucleosome-Binding Domain-Containing Protein 1" @default.
- NCIT_C19934 hasExactSynonym "High Mobility Group Protein 14" @default.
- NCIT_C19934 hasExactSynonym "High-Mobility Group (Nonhistone Chromosomal) Protein 14" @default.
- NCIT_C19934 hasExactSynonym "High-Mobility Group Nucleosome Binding 1" @default.
- NCIT_C19934 hasExactSynonym "High-Mobility Group Nucleosome Binding Domain 1" @default.
- NCIT_C19934 hasExactSynonym "Non-Histone Chromosomal Protein HMG-14" @default.
- NCIT_C19934 hasExactSynonym "Nonhistone Chromosomal Protein HMG-14" @default.
- NCIT_C19934 hasExactSynonym "Nonhistone Chromosomal Protein HMG14" @default.
- NCIT_C19934 type Class @default.
- NCIT_C19934 isDefinedBy ncit.owl @default.
- NCIT_C19934 label "Non-Histone Chromosomal Protein HMG-14" @default.
- NCIT_C19934 subClassOf NCIT_C17021 @default.
- NCIT_C19934 subClassOf NCIT_C18466 @default.
- NCIT_C19934 subClassOf NCIT_C19934 @default.
- NCIT_C19934 subClassOf NCIT_C20027 @default.
- NCIT_C19934 subClassOf NCIT_C26199 @default.
- NCIT_C19934 subClassOf NCIT_C26548 @default.
- NCIT_C19934 equivalentClass B564be7e9dab8cd4c67119519fbf26080 @default.
- NCIT_C19934 equivalentClass B76295bbfebdbfbbd042c5ab1bc21a4d2 @default.