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- NCIT_C199480 IAO_0000115 "A radioconjugate composed of the melanocyte-stimulating hormone receptor (MSHR; melanocortin-1 receptor; MC1R; melanin-activating peptide receptor; melanotropin receptor)-targeting peptide, VMT01, conjugated to the alpha-emitting radioisotope lead Pb 212, with potential antineoplastic activity. Upon administration, lead Pb 212-VMT01 targets and binds to MC1R-expressing tumor cells. This allows for the specific delivery of a cytotoxic dose of alpha radiation to MC1R-expressing tumor cells. MC1R, a G protein-coupled receptor expressed by melanocytes that binds to melanocortins, is involved in regulating mammalian skin and hair color. It is upregulated on the surface of metastatic melanoma cells." @default.
- NCIT_C199480 NCIT_A7 NCIT_C48827 @default.
- NCIT_C199480 NCIT_NHC0 "C199480" @default.
- NCIT_C199480 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199480 NCIT_P107 "Lead Pb 212-VMT01" @default.
- NCIT_C199480 NCIT_P108 "Lead Pb 212-VMT01" @default.
- NCIT_C199480 NCIT_P322 "CTRP" @default.
- NCIT_C199480 NCIT_P322 "GDC" @default.
- NCIT_C199480 NCIT_P399 "812744" @default.
- NCIT_C199480 normalizedInformationContent "100" @default.
- NCIT_C199480 referenceCount "1" @default.
- NCIT_C199480 hasExactSynonym "Lead Pb 212 VMT01" @default.
- NCIT_C199480 hasExactSynonym "Lead Pb 212-VMT01" @default.
- NCIT_C199480 hasExactSynonym "[212Pb]VMT01" @default.
- NCIT_C199480 inSubset NCIT_C116977 @default.
- NCIT_C199480 inSubset NCIT_C116978 @default.
- NCIT_C199480 inSubset NCIT_C128784 @default.
- NCIT_C199480 inSubset NCIT_C157711 @default.
- NCIT_C199480 inSubset NCIT_C157712 @default.
- NCIT_C199480 inSubset NCIT_C176424 @default.
- NCIT_C199480 type Class @default.
- NCIT_C199480 isDefinedBy ncit.owl @default.
- NCIT_C199480 label "Lead Pb 212-VMT01" @default.
- NCIT_C199480 subClassOf NCIT_C129819 @default.
- NCIT_C199480 subClassOf NCIT_C1446 @default.
- NCIT_C199480 subClassOf NCIT_C1908 @default.
- NCIT_C199480 subClassOf NCIT_C1909 @default.
- NCIT_C199480 subClassOf NCIT_C199480 @default.
- NCIT_C199480 subClassOf NCIT_C200225 @default.
- NCIT_C199480 subClassOf NCIT_C2124 @default.
- NCIT_C199480 subClassOf NCIT_C274 @default.