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- NCIT_C199570 IAO_0000115 "An Fc-silenced bispecific antibody against both the tumor-associated antigen (TAA) B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1) and the costimulatory receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential checkpoint inhibitory, immunostimulating and antineoplastic activities. Upon administration, anti-B7-H4/anti-4-1BB bispecific antibody CLN-418 targets and binds to both B7-H4 expressed on the surface of tumor cells and 4-1BB expressed on activated T-lymphocytes, natural killer (NK) cells and NK-T-cells. This crosslinks B7-H4-expressing tumor cells and 4-1BB-expressing T-cells, NK cells and NK-T-cells, and activates 4-1BB signaling locally in the tumor microenvironment (TME). This induces cytotoxic T-lymphocyte (CTL) proliferation, cytokine production and promotes a CTL-mediated anti-tumor immune response against tumor cells, induces NK-mediated tumor cell killing, and suppresses the immunosuppressive activity of regulatory T-cells (Tregs). B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and negatively regulates T-cell immune responses. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity." @default.
- NCIT_C199570 NCIT_A7 NCIT_C106223 @default.
- NCIT_C199570 NCIT_NHC0 "C199570" @default.
- NCIT_C199570 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199570 NCIT_P107 "Anti-B7-H4/Anti-4-1BB Bispecific Antibody CLN-418" @default.
- NCIT_C199570 NCIT_P108 "Anti-B7-H4/Anti-4-1BB Bispecific Antibody CLN-418" @default.
- NCIT_C199570 NCIT_P322 "CTRP" @default.
- NCIT_C199570 NCIT_P322 "GDC" @default.
- NCIT_C199570 NCIT_P399 "812964" @default.
- NCIT_C199570 NCIT_R124 NCIT_C17710 @default.
- NCIT_C199570 NCIT_R124 NCIT_C17828 @default.
- NCIT_C199570 NCIT_R124 NCIT_C18219 @default.
- NCIT_C199570 NCIT_R124 NCIT_C19986 @default.
- NCIT_C199570 NCIT_R124 NCIT_C40474 @default.
- NCIT_C199570 normalizedInformationContent "100" @default.
- NCIT_C199570 referenceCount "1" @default.
- NCIT_C199570 hasExactSynonym "Anti-B7-H4/Anti-4-1BB Bispecific Antibody CLN-418" @default.
- NCIT_C199570 hasExactSynonym "Anti-B7-H4/Anti-4-1BB Bispecific Antibody HBM7008" @default.
- NCIT_C199570 hasExactSynonym "Anti-B7-H4/Anti-4-1BB Bispecific Immune Activator CLN-418" @default.
- NCIT_C199570 hasExactSynonym "CLN 418" @default.
- NCIT_C199570 hasExactSynonym "CLN-418" @default.
- NCIT_C199570 hasExactSynonym "CLN418" @default.
- NCIT_C199570 hasExactSynonym "HBM 7008" @default.
- NCIT_C199570 hasExactSynonym "HBM-7008" @default.
- NCIT_C199570 hasExactSynonym "HBM7008" @default.
- NCIT_C199570 inSubset NCIT_C116977 @default.
- NCIT_C199570 inSubset NCIT_C116978 @default.
- NCIT_C199570 inSubset NCIT_C128784 @default.
- NCIT_C199570 inSubset NCIT_C157711 @default.
- NCIT_C199570 inSubset NCIT_C157712 @default.
- NCIT_C199570 inSubset NCIT_C176424 @default.
- NCIT_C199570 type Class @default.
- NCIT_C199570 isDefinedBy ncit.owl @default.
- NCIT_C199570 label "Anti-B7-H4/Anti-4-1BB Bispecific Antibody CLN-418" @default.
- NCIT_C199570 subClassOf NCIT_C129820 @default.
- NCIT_C199570 subClassOf NCIT_C129821 @default.
- NCIT_C199570 subClassOf NCIT_C129822 @default.
- NCIT_C199570 subClassOf NCIT_C1454 @default.
- NCIT_C199570 subClassOf NCIT_C163758 @default.
- NCIT_C199570 subClassOf NCIT_C1908 @default.
- NCIT_C199570 subClassOf NCIT_C1909 @default.
- NCIT_C199570 subClassOf NCIT_C192997 @default.
- NCIT_C199570 subClassOf NCIT_C199433 @default.
- NCIT_C199570 subClassOf NCIT_C199488 @default.
- NCIT_C199570 subClassOf NCIT_C199570 @default.
- NCIT_C199570 subClassOf NCIT_C20401 @default.
- NCIT_C199570 subClassOf NCIT_C274 @default.
- NCIT_C199570 subClassOf NCIT_C28227 @default.
- NCIT_C199570 subClassOf NCIT_C307 @default.
- NCIT_C199570 subClassOf NCIT_C308 @default.