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- NCIT_C199574 IAO_0000115 "A protease-activated, double masked tumor activated T-cell engager (TCE) composed of a tumor-associated antigen (TAA) binding domain that targets epidermal growth factor receptor (EGFR) and a T-cell binding domain that targets CD3, that are both conjugated, via a tumor protease-cleavable linker, to a peptide mask that prevents binding of the EGFR-binding domain to EGFR-expressing tumor cells and binding of the CD3-binding domain to T-cells, respectively, and an albumin-binding domain that extends circulating half-life, with potential immunomodulating and antineoplastic activities. Upon intravenous administration of anti-EGFR/anti-CD3 tumor protease-activated TCE JANX008, the tumor protease-cleavable linkers are proteolytically cleaved in the tumor microenvironment (TME), which separates both the EGFR-binding domain and the CD3-binding domain of JANX008 from their respective peptide masks, thereby allowing the binding domains to bind to their respective targets. The EGFR-binding domain targets and binds to EGFR expressed on tumor cells. The CD3-binding domain targets and binds to T-cells. The resulting cross-linkage triggers a cytotoxic T-lymphocyte (CTL) response against EGFR-expressing tumor cells in the TME. EGFR, a receptor tyrosine kinase, is overexpressed on the surfaces of various tumor cell types. The albumin-binding domain, which is attached to the CD3-binding domain mask, binds to albumin in the circulation, thereby extending the half-life of JANX008. While in circulation, the two tumor protease-cleavable peptide masks inhibit EGFR and CD3 binding and may prevent cytokine release syndrome (CRS) and on-target EGFR healthy tissue toxicity while increasing its efficacy when activated in the TME." @default.
- NCIT_C199574 NCIT_A7 NCIT_C17068 @default.
- NCIT_C199574 NCIT_NHC0 "C199574" @default.
- NCIT_C199574 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199574 NCIT_P107 "Anti-EGFR/anti-CD3 Tumor Protease-activated T-cell Engager JANX008" @default.
- NCIT_C199574 NCIT_P108 "Anti-EGFR/anti-CD3 Tumor Protease-activated T-cell Engager JANX008" @default.
- NCIT_C199574 NCIT_P322 "CTRP" @default.
- NCIT_C199574 NCIT_P322 "GDC" @default.
- NCIT_C199574 NCIT_P399 "812856" @default.
- NCIT_C199574 NCIT_R124 NCIT_C17710 @default.
- NCIT_C199574 NCIT_R124 NCIT_C17828 @default.
- NCIT_C199574 NCIT_R124 NCIT_C18219 @default.
- NCIT_C199574 NCIT_R124 NCIT_C19986 @default.
- NCIT_C199574 NCIT_R124 NCIT_C40474 @default.
- NCIT_C199574 normalizedInformationContent "100" @default.
- NCIT_C199574 referenceCount "1" @default.
- NCIT_C199574 hasExactSynonym "Anti-EGFR/Anti-CD3 Protease-activated TCE JANX008" @default.
- NCIT_C199574 hasExactSynonym "Anti-EGFR/CD3 Protease-activated TCE JANX008" @default.
- NCIT_C199574 hasExactSynonym "Anti-EGFR/anti-CD3 Tumor Protease-activated T-cell Engager JANX008" @default.
- NCIT_C199574 hasExactSynonym "Double Masked EGFR TCE JANX008" @default.
- NCIT_C199574 hasExactSynonym "Double-masked Tumor Activated T Cell Engager JANX008" @default.
- NCIT_C199574 hasExactSynonym "EGFR-TRACTr JANX008" @default.
- NCIT_C199574 hasExactSynonym "EGFR-targeted TRACTr JANX008" @default.
- NCIT_C199574 hasExactSynonym "EGFR-targeted Tumor-activated T Cell Engager JANX008" @default.
- NCIT_C199574 hasExactSynonym "JANX 008" @default.
- NCIT_C199574 hasExactSynonym "JANX-008" @default.
- NCIT_C199574 hasExactSynonym "JANX008" @default.
- NCIT_C199574 inSubset NCIT_C116977 @default.
- NCIT_C199574 inSubset NCIT_C116978 @default.
- NCIT_C199574 inSubset NCIT_C128784 @default.
- NCIT_C199574 inSubset NCIT_C157711 @default.
- NCIT_C199574 inSubset NCIT_C157712 @default.
- NCIT_C199574 inSubset NCIT_C176424 @default.
- NCIT_C199574 type Class @default.
- NCIT_C199574 isDefinedBy ncit.owl @default.
- NCIT_C199574 label "Anti-EGFR/anti-CD3 Tumor Protease-activated T-cell Engager JANX008" @default.
- NCIT_C199574 subClassOf NCIT_C1454 @default.
- NCIT_C199574 subClassOf NCIT_C163758 @default.
- NCIT_C199574 subClassOf NCIT_C163952 @default.
- NCIT_C199574 subClassOf NCIT_C1908 @default.
- NCIT_C199574 subClassOf NCIT_C1909 @default.
- NCIT_C199574 subClassOf NCIT_C199574 @default.
- NCIT_C199574 subClassOf NCIT_C20401 @default.
- NCIT_C199574 subClassOf NCIT_C274 @default.
- NCIT_C199574 subClassOf NCIT_C28227 @default.
- NCIT_C199574 subClassOf NCIT_C307 @default.
- NCIT_C199574 subClassOf NCIT_C308 @default.