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- NCIT_C199579 IAO_0000115 "An orally bioavailable fixed combination of bictegravir sodium, the sodium salt form of the human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) bictegravir, emtricitabine, a nucleoside reverse transcriptase (RT) inhibitor (NRTI) analog of cytidine, and tenofovir alafenamide fumarate, the fumarate salt form of the lipophilic phosphonamidate prodrug of tenofovir, a NRTI analog of adenosine monophosphate, that is used to treat human immunodeficiency virus (HIV) infection. Upon oral administration of bictegravir/emtricitabine/tenofovir alafenamide, bictegravir inhibits the strand transfer activity of HIV-1 integrase, an HIV-1 coded enzyme that is necessary for viral replication. Inhibition of integrase prevents the integration of linear HIV-1 DNA into host genomic DNA. Emtricitabine and tenofovir inhibit the activity of HIV RT by competing with natural deoxyribonucleosides for incorporation into the growing viral DNA chain resulting in early chain termination. This interferes with the generation of DNA copies of viral RNA, which is necessary for the synthesis of new virions." @default.
- NCIT_C199579 NCIT_NHC0 "C199579" @default.
- NCIT_C199579 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199579 NCIT_P108 "Bictegravir Sodium/Emtricitabine/Tenofovir Alafenamide Fumarate" @default.
- NCIT_C199579 normalizedInformationContent "100" @default.
- NCIT_C199579 referenceCount "1" @default.
- NCIT_C199579 hasExactSynonym "Bictegravir Sodium/Emtricitabine/Tenofovir Alafenamide Fumarate" @default.
- NCIT_C199579 hasExactSynonym "Biktarvy" @default.
- NCIT_C199579 type Class @default.
- NCIT_C199579 isDefinedBy ncit.owl @default.
- NCIT_C199579 label "Bictegravir Sodium/Emtricitabine/Tenofovir Alafenamide Fumarate" @default.
- NCIT_C199579 subClassOf NCIT_C157401 @default.
- NCIT_C199579 subClassOf NCIT_C1589 @default.
- NCIT_C199579 subClassOf NCIT_C1660 @default.
- NCIT_C199579 subClassOf NCIT_C1908 @default.
- NCIT_C199579 subClassOf NCIT_C1909 @default.
- NCIT_C199579 subClassOf NCIT_C199579 @default.
- NCIT_C199579 subClassOf NCIT_C254 @default.
- NCIT_C199579 subClassOf NCIT_C281 @default.
- NCIT_C199579 subClassOf NCIT_C471 @default.