Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C199584> ?p ?o ?g. }
Showing items 1 to 34 of
34
with 100 items per page.
- NCIT_C199584 IAO_0000115 "An antibody-drug conjugate (ADC) composed of OMTX005, a humanized monoclonal antibody directed against fibroblast activation protein (FAP), conjugated to the cytotoxic tubulysin TAM470, with potential antineoplastic activity. Upon administration of anti-FAP ADC OMTX705, the anti-FAP monoclonal antibody moiety targets and binds to FAP expressed on cancer-associated fibroblasts (CAFs) in the tumor stroma. Upon binding, internalization and linker cleavage, the cytotoxic moiety is released, which binds to tubulin and inhibits microtubule polymerization. This results in G2/M phase arrest and the apoptosis of FAP-expressing CAFs. FAP, a membrane-bound serine protease overexpressed on CAFs, is minimally expressed on normal, healthy cells." @default.
- NCIT_C199584 NCIT_A7 NCIT_C17799 @default.
- NCIT_C199584 NCIT_NHC0 "C199584" @default.
- NCIT_C199584 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199584 NCIT_P107 "Anti-FAP Antibody-drug Conjugate OMTX705" @default.
- NCIT_C199584 NCIT_P108 "Anti-FAP Antibody-drug Conjugate OMTX705" @default.
- NCIT_C199584 NCIT_P322 "CTRP" @default.
- NCIT_C199584 NCIT_P322 "GDC" @default.
- NCIT_C199584 NCIT_P399 "812965" @default.
- NCIT_C199584 normalizedInformationContent "100" @default.
- NCIT_C199584 referenceCount "1" @default.
- NCIT_C199584 hasExactSynonym "Anti-FAP ADC OMTX705" @default.
- NCIT_C199584 hasExactSynonym "Anti-FAP Antibody-drug Conjugate OMTX705" @default.
- NCIT_C199584 hasExactSynonym "OMTX 705" @default.
- NCIT_C199584 hasExactSynonym "OMTX-705" @default.
- NCIT_C199584 hasExactSynonym "OMTX705" @default.
- NCIT_C199584 inSubset NCIT_C116977 @default.
- NCIT_C199584 inSubset NCIT_C116978 @default.
- NCIT_C199584 inSubset NCIT_C128784 @default.
- NCIT_C199584 inSubset NCIT_C157711 @default.
- NCIT_C199584 inSubset NCIT_C157712 @default.
- NCIT_C199584 inSubset NCIT_C176424 @default.
- NCIT_C199584 type Class @default.
- NCIT_C199584 isDefinedBy ncit.owl @default.
- NCIT_C199584 label "Anti-FAP Antibody-drug Conjugate OMTX705" @default.
- NCIT_C199584 subClassOf NCIT_C129821 @default.
- NCIT_C199584 subClassOf NCIT_C129823 @default.
- NCIT_C199584 subClassOf NCIT_C1512 @default.
- NCIT_C199584 subClassOf NCIT_C1908 @default.
- NCIT_C199584 subClassOf NCIT_C1909 @default.
- NCIT_C199584 subClassOf NCIT_C199584 @default.
- NCIT_C199584 subClassOf NCIT_C274 @default.
- NCIT_C199584 subClassOf NCIT_C307 @default.
- NCIT_C199584 subClassOf NCIT_C308 @default.