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- NCIT_C199613 IAO_0000115 "A recombinant, non-replicative, modified vaccinia virus Ankara (MVA) engineered with the deletion of the vaccinia E5R gene and the expression of two membrane-anchored transgenes, fms-like tyrosine kinase 3 ligand (Flt3L) and OX40 ligand (OX40L), with potential immunostimulatory and antineoplastic activities. Upon intratumoral administration, MVA expressing Flt3L/OX40L MQ710 is transduced into tumor cells and Flt3L and OX40L are expressed. The recombinant MVA, with the deletion of the E5R gene, activates the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway and increases type I interferon (IFN) production. Flt3L binds to the Flt3 tyrosine kinase receptor and promotes Flt3 signaling, thereby expanding the population of antigen-presenting dendritic cells (DCs). OX40L binds to and activates signaling pathways downstream of its cognate receptor, tumor necrosis factor receptor superfamily member 4 (TNFRSF4; OX40), which is expressed on activated T-cells and regulatory T-cells (Tregs). This causes depletion of OX40-expressing Tregs in the tumor microenvironment (TME) via OX40L-OX40 interaction and is facilitated by the rMVA-induced type I IFN and IFN-I receptor (IFNAR)-mediated signaling. This inhibits Treg-mediated suppression of effector T-cells, induces the proliferation of memory and effector T-lymphocytes and increases cytokine production. Altogether, MQ710 promotes immune activation and anti-tumor immune responses." @default.
- NCIT_C199613 NCIT_A7 NCIT_C26202 @default.
- NCIT_C199613 NCIT_A7 NCIT_C94790 @default.
- NCIT_C199613 NCIT_NHC0 "C199613" @default.
- NCIT_C199613 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199613 NCIT_P107 "Modified Vaccinia Virus Ankara Expressing Flt3L/OX40L MQ710" @default.
- NCIT_C199613 NCIT_P108 "Modified Vaccinia Virus Ankara Expressing Flt3L/OX40L MQ710" @default.
- NCIT_C199613 NCIT_P322 "CTRP" @default.
- NCIT_C199613 NCIT_P322 "GDC" @default.
- NCIT_C199613 NCIT_P399 "812970" @default.
- NCIT_C199613 normalizedInformationContent "100" @default.
- NCIT_C199613 referenceCount "1" @default.
- NCIT_C199613 hasExactSynonym "MQ 710" @default.
- NCIT_C199613 hasExactSynonym "MQ-710" @default.
- NCIT_C199613 hasExactSynonym "MQ710" @default.
- NCIT_C199613 hasExactSynonym "MVA Expressing Flt3L/OX40L MQ710" @default.
- NCIT_C199613 hasExactSynonym "MVAdeltaE5R-Flt3L-OX40L" @default.
- NCIT_C199613 hasExactSynonym "Modified Vaccinia Virus Ankara Expressing Flt3L/OX40L MQ710" @default.
- NCIT_C199613 hasExactSynonym "rMVA Expressing Flt3L/OX40L MQ710" @default.
- NCIT_C199613 inSubset NCIT_C116977 @default.
- NCIT_C199613 inSubset NCIT_C116978 @default.
- NCIT_C199613 inSubset NCIT_C128784 @default.
- NCIT_C199613 inSubset NCIT_C157711 @default.
- NCIT_C199613 inSubset NCIT_C157712 @default.
- NCIT_C199613 inSubset NCIT_C176424 @default.
- NCIT_C199613 type Class @default.
- NCIT_C199613 isDefinedBy ncit.owl @default.
- NCIT_C199613 label "Modified Vaccinia Virus Ankara Expressing Flt3L/OX40L MQ710" @default.
- NCIT_C199613 subClassOf NCIT_C129820 @default.
- NCIT_C199613 subClassOf NCIT_C1908 @default.
- NCIT_C199613 subClassOf NCIT_C1909 @default.
- NCIT_C199613 subClassOf NCIT_C1962 @default.
- NCIT_C199613 subClassOf NCIT_C199613 @default.
- NCIT_C199613 subClassOf NCIT_C274 @default.
- NCIT_C199613 subClassOf NCIT_C307 @default.
- NCIT_C199613 subClassOf NCIT_C308 @default.