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- NCIT_C199622 IAO_0000115 "A preparation of off-the-shelf (OTS), allogeneic natural killer (NK) cells, derived from genetically engineered human induced pluripotent stem cells (iPSCs), that are genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 33 (CD33), and containing a high-affinity, non-cleavable CD16 (hnCD16) to enhance antibody-dependent cell-mediated cytotoxicity (ADCC), an interleukin-15 (IL-15) molecule to increase the persistence of allogeneic cells in vivo, and a CD38 knockout to avoid depletion of CAR-NK cells, with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic anti-CD33 CAR-NK cells QN-023a recognize, bind to and induce selective cytotoxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells." @default.
- NCIT_C199622 NCIT_A7 NCIT_C97246 @default.
- NCIT_C199622 NCIT_NHC0 "C199622" @default.
- NCIT_C199622 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199622 NCIT_P108 "Allogeneic Anti-CD33 CAR-NK Cells QN-023a" @default.
- NCIT_C199622 NCIT_P322 "GDC" @default.
- NCIT_C199622 NCIT_P399 "812477" @default.
- NCIT_C199622 normalizedInformationContent "100" @default.
- NCIT_C199622 referenceCount "1" @default.
- NCIT_C199622 hasExactSynonym "Allogeneic Anti-CD33 CAR-NK Cells QN-023a" @default.
- NCIT_C199622 hasExactSynonym "Allogeneic CD33-CAR iNKs QN-023a" @default.
- NCIT_C199622 hasExactSynonym "Allogeneic iPSC-derived NK Cells QN-023a" @default.
- NCIT_C199622 hasExactSynonym "QN 023a" @default.
- NCIT_C199622 hasExactSynonym "QN-023a" @default.
- NCIT_C199622 hasExactSynonym "QN023a" @default.
- NCIT_C199622 inSubset NCIT_C128784 @default.
- NCIT_C199622 inSubset NCIT_C157711 @default.
- NCIT_C199622 inSubset NCIT_C157712 @default.
- NCIT_C199622 inSubset NCIT_C176424 @default.
- NCIT_C199622 type Class @default.
- NCIT_C199622 isDefinedBy ncit.owl @default.
- NCIT_C199622 label "Allogeneic Anti-CD33 CAR-NK Cells QN-023a" @default.
- NCIT_C199622 subClassOf NCIT_C129820 @default.
- NCIT_C199622 subClassOf NCIT_C129821 @default.
- NCIT_C199622 subClassOf NCIT_C129826 @default.
- NCIT_C199622 subClassOf NCIT_C142078 @default.
- NCIT_C199622 subClassOf NCIT_C1908 @default.
- NCIT_C199622 subClassOf NCIT_C1909 @default.
- NCIT_C199622 subClassOf NCIT_C199622 @default.
- NCIT_C199622 subClassOf NCIT_C201545 @default.
- NCIT_C199622 subClassOf NCIT_C274 @default.
- NCIT_C199622 subClassOf NCIT_C28676 @default.
- NCIT_C199622 subClassOf NCIT_C307 @default.
- NCIT_C199622 subClassOf NCIT_C308 @default.