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- NCIT_C199623 IAO_0000115 "A multi-specific T-cell engaging designed ankyrin repeat proteins (DARPin) composed of a chain of six covalently linked DARPin domains of which three domains target the three tumor-associated antigens (TAAs) cluster of differentiation 33 (CD33), CD123 and CD70, one domain targets CD3 on T-cells and two domains target human serum albumin (HSA) to prolong half-life, with potential immunomodulating and antineoplastic activities. Upon administration, anti-CD33/CD123/CD70 DARPin CD3 engager MP0533 selectively targets and binds to CD33, CD123 and CD70 that are expressed on a variety of tumor cells. The simultaneous binding of the CD3-targeting DARPin domain of MP0533 to T-cells results in local clustering of the TAA-expressing tumor cells and T-cells, and local immune cell activation through the promotion of T-cell activation, cytokine and chemokine release and T-cell-mediated anti-tumor immune responses. CD33, CD123 and CD70 are all present on acute myeloid leukemia (AML) cells and are more likely to be expressed together on AML blast cells and leukemic stem cells (LSCs) than on healthy cells, such as hematopoietic stem cells (HSCs), that may express a single TAA. The binding of MP0533 to either two or three TAAs enhances its selectivity for AML cells over healthy cells." @default.
- NCIT_C199623 NCIT_A7 NCIT_C104079 @default.
- NCIT_C199623 NCIT_A7 NCIT_C39275 @default.
- NCIT_C199623 NCIT_A7 NCIT_C97246 @default.
- NCIT_C199623 NCIT_NHC0 "C199623" @default.
- NCIT_C199623 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C199623 NCIT_P108 "Anti-CD33/CD123/CD70 DARPin CD3 Engager MP0533" @default.
- NCIT_C199623 NCIT_P322 "GDC" @default.
- NCIT_C199623 NCIT_P399 "812478" @default.
- NCIT_C199623 normalizedInformationContent "100" @default.
- NCIT_C199623 referenceCount "1" @default.
- NCIT_C199623 hasExactSynonym "Anti-CD33/CD123/CD70 DARPin CD3 Engager MP0533" @default.
- NCIT_C199623 hasExactSynonym "CD33/CD123/CD70-targeting DARPin MP0533" @default.
- NCIT_C199623 hasExactSynonym "DARPin T-cell Engager MP0533" @default.
- NCIT_C199623 hasExactSynonym "MP 0533" @default.
- NCIT_C199623 hasExactSynonym "MP-0533" @default.
- NCIT_C199623 hasExactSynonym "MP0533" @default.
- NCIT_C199623 hasExactSynonym "Multispecific DARPin CD3 Engager Targeting CD33/CD123/CD70 MP0533" @default.
- NCIT_C199623 inSubset NCIT_C128784 @default.
- NCIT_C199623 inSubset NCIT_C157711 @default.
- NCIT_C199623 inSubset NCIT_C157712 @default.
- NCIT_C199623 inSubset NCIT_C176424 @default.
- NCIT_C199623 type Class @default.
- NCIT_C199623 isDefinedBy ncit.owl @default.
- NCIT_C199623 label "Anti-CD33/CD123/CD70 DARPin CD3 Engager MP0533" @default.
- NCIT_C199623 subClassOf NCIT_C129824 @default.
- NCIT_C199623 subClassOf NCIT_C163758 @default.
- NCIT_C199623 subClassOf NCIT_C1908 @default.
- NCIT_C199623 subClassOf NCIT_C1909 @default.
- NCIT_C199623 subClassOf NCIT_C199623 @default.
- NCIT_C199623 subClassOf NCIT_C200042 @default.
- NCIT_C199623 subClassOf NCIT_C2189 @default.
- NCIT_C199623 subClassOf NCIT_C274 @default.