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- NCIT_C199626 IAO_0000115 "A fusion protein composed of MDK-1472, a structurally unrelated engineered mimetic peptide of endogenous human cytokine interleukin-7 (hIL-7), fused to an immunoglobulin G2 (IgG2) Fc-domain, with hematopoietic and immunopotentiating activities. Upon administration, Fc fusion IL-7 mimetic MDK-703 mimics endogenous cytokine IL-7 and binds to the IL-7 receptor (IL7R) on immune cells. The binding of IL-7 to IL7R activates IL7/IL7R-mediated signaling, which leads to the expansion of various subsets of T-lymphocytes, including memory T-cells, especially CD8 and CD4 stem cell memory T-cells (Tscm), central memory T-cells (Tcm) and effector memory T-cells (Tem). This may improve immune recovery and activation and may enhance T-cell-mediated anti-tumor immune responses. Fusion to the Fc domain enhances the half-life of the IL-7 mimetic. As MDK-703 is unrelated in sequence to the natural cytokine, it is unlikely to generate anti-drug antibodies (ADAs) that neutralize the endogenous IL-7 cytokine. IL-7 is a cytokine critical for the development, maintenance and survival of T-cell subpopulations." @default.
- NCIT_C199626 NCIT_A7 NCIT_C26278 @default.
- NCIT_C199626 NCIT_NHC0 "C199626" @default.
- NCIT_C199626 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C199626 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C199626 NCIT_P107 "Fc Fusion IL-7 Mimetic MDK-703" @default.
- NCIT_C199626 NCIT_P108 "Fc Fusion IL-7 Mimetic MDK-703" @default.
- NCIT_C199626 NCIT_P322 "CTRP" @default.
- NCIT_C199626 NCIT_P322 "GDC" @default.
- NCIT_C199626 NCIT_P399 "812540" @default.
- NCIT_C199626 NCIT_R124 NCIT_C17828 @default.
- NCIT_C199626 NCIT_R124 NCIT_C18992 @default.
- NCIT_C199626 NCIT_R124 NCIT_C19143 @default.
- NCIT_C199626 NCIT_R124 NCIT_C21124 @default.
- NCIT_C199626 NCIT_R124 NCIT_C40702 @default.
- NCIT_C199626 NCIT_R125 NCIT_C17828 @default.
- NCIT_C199626 NCIT_R125 NCIT_C17937 @default.
- NCIT_C199626 NCIT_R125 NCIT_C18081 @default.
- NCIT_C199626 NCIT_R125 NCIT_C18095 @default.
- NCIT_C199626 NCIT_R125 NCIT_C18839 @default.
- NCIT_C199626 NCIT_R125 NCIT_C20480 @default.
- NCIT_C199626 NCIT_R125 NCIT_C20751 @default.
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- NCIT_C199626 NCIT_R125 NCIT_C26280 @default.
- NCIT_C199626 NCIT_R125 NCIT_C40833 @default.
- NCIT_C199626 NCIT_R125 NCIT_C40912 @default.
- NCIT_C199626 normalizedInformationContent "100" @default.
- NCIT_C199626 referenceCount "1" @default.
- NCIT_C199626 hasExactSynonym "Fc Fusion IL-7 Mimetic MDK-703" @default.
- NCIT_C199626 hasExactSynonym "Fc-Peptide-Based IL-7 Mimetic MDK-703" @default.
- NCIT_C199626 hasExactSynonym "IL-7 Mimetic MDK-703" @default.
- NCIT_C199626 hasExactSynonym "IL-7 PEPTIKINE-Fc-domain Fusion Protein MDK-703" @default.
- NCIT_C199626 hasExactSynonym "IL-7R Agonist MDK-703" @default.
- NCIT_C199626 hasExactSynonym "MDK 703" @default.
- NCIT_C199626 hasExactSynonym "MDK-703" @default.
- NCIT_C199626 hasExactSynonym "MDK703" @default.
- NCIT_C199626 inSubset NCIT_C116977 @default.
- NCIT_C199626 inSubset NCIT_C116978 @default.
- NCIT_C199626 inSubset NCIT_C128784 @default.
- NCIT_C199626 inSubset NCIT_C157711 @default.
- NCIT_C199626 inSubset NCIT_C157712 @default.
- NCIT_C199626 inSubset NCIT_C176424 @default.
- NCIT_C199626 type Class @default.
- NCIT_C199626 isDefinedBy ncit.owl @default.
- NCIT_C199626 label "Fc Fusion IL-7 Mimetic MDK-703" @default.
- NCIT_C199626 subClassOf NCIT_C1283 @default.
- NCIT_C199626 subClassOf NCIT_C1908 @default.
- NCIT_C199626 subClassOf NCIT_C1909 @default.
- NCIT_C199626 subClassOf NCIT_C199626 @default.
- NCIT_C199626 subClassOf NCIT_C307 @default.
- NCIT_C199626 subClassOf NCIT_C308 @default.
- NCIT_C199626 subClassOf NCIT_C592 @default.
- NCIT_C199626 subClassOf NCIT_C593 @default.