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- NCIT_C200038 IAO_0000115 "A central nervous system (CNS)-penetrant inhibitor of the serine/threonine protein kinase Raf family, with potential antineoplastic activity. Upon oral administration, BDTX-4933 selectively targets, binds to and inhibits the activity of activated RAF that results from BRAF monomeric (class I), and dimeric class II (Ras-independent) and class III (Ras-dependent) mutations, and RAS mutations, which may inhibit the proliferation of tumor cells expressing a mutated BRAF, KRAS or NRAS gene. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types. They play key roles in tumor cell proliferation and survival. BRAF, a serine/threonine protein kinase, plays a key role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. Ras serves an important role in cell signaling, division and differentiation. Mutations of Ras may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis." @default.
- NCIT_C200038 NCIT_NHC0 "C200038" @default.
- NCIT_C200038 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200038 NCIT_P107 "RAF Inhibitor BDTX-4933" @default.
- NCIT_C200038 NCIT_P108 "RAF Inhibitor BDTX-4933" @default.
- NCIT_C200038 NCIT_P322 "CTRP" @default.
- NCIT_C200038 NCIT_P399 "812843" @default.
- NCIT_C200038 normalizedInformationContent "100" @default.
- NCIT_C200038 referenceCount "1" @default.
- NCIT_C200038 hasExactSynonym "BDTX 4933" @default.
- NCIT_C200038 hasExactSynonym "BDTX-4933" @default.
- NCIT_C200038 hasExactSynonym "BDTX4933" @default.
- NCIT_C200038 hasExactSynonym "RAF Inhibitor BDTX-4933" @default.
- NCIT_C200038 hasExactSynonym "RAF Kinase Inhibitor BDTX-4933" @default.
- NCIT_C200038 inSubset NCIT_C116977 @default.
- NCIT_C200038 inSubset NCIT_C116978 @default.
- NCIT_C200038 inSubset NCIT_C176424 @default.
- NCIT_C200038 type Class @default.
- NCIT_C200038 isDefinedBy ncit.owl @default.
- NCIT_C200038 label "RAF Inhibitor BDTX-4933" @default.
- NCIT_C200038 subClassOf NCIT_C129824 @default.
- NCIT_C200038 subClassOf NCIT_C129825 @default.
- NCIT_C200038 subClassOf NCIT_C1404 @default.
- NCIT_C200038 subClassOf NCIT_C163758 @default.
- NCIT_C200038 subClassOf NCIT_C1908 @default.
- NCIT_C200038 subClassOf NCIT_C1909 @default.
- NCIT_C200038 subClassOf NCIT_C200038 @default.
- NCIT_C200038 subClassOf NCIT_C2189 @default.
- NCIT_C200038 subClassOf NCIT_C2336 @default.
- NCIT_C200038 subClassOf NCIT_C274 @default.
- NCIT_C200038 subClassOf NCIT_C471 @default.
- NCIT_C200038 subClassOf NCIT_C61074 @default.