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- NCIT_C200041 IAO_0000115 "A preparation of human allogeneic T-lymphocytes gene-edited with the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease complex to disrupt expression of endogenous TCR and major histocompatibility complex (MHC) class I molecules and modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human cluster of differentiation 70 (CD70), with potential immunostimulating and antineoplastic activities. Upon introduction into the patient, the allogeneic CRISPR-Cas9 engineered anti-CD70 CAR T-cells CTX131 recognize and bind to CD70-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD70-positive tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells. Disruption of endogenous TCR prevents graft-versus-host disease (GvHD); the disruption of MHC class I molecules increases the persistence of the CAR T-cells." @default.
- NCIT_C200041 NCIT_NHC0 "C200041" @default.
- NCIT_C200041 NCIT_P106 "Cell" @default.
- NCIT_C200041 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200041 NCIT_P107 "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX131" @default.
- NCIT_C200041 NCIT_P108 "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX131" @default.
- NCIT_C200041 NCIT_P322 "CTRP" @default.
- NCIT_C200041 NCIT_P399 "812928" @default.
- NCIT_C200041 normalizedInformationContent "100" @default.
- NCIT_C200041 referenceCount "1" @default.
- NCIT_C200041 hasExactSynonym "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX131" @default.
- NCIT_C200041 hasExactSynonym "Allogeneic CRISPR-Cas9-engineered T Cells CTX131" @default.
- NCIT_C200041 hasExactSynonym "CRISPR/Cas9 Gene-edited Allogeneic Anti-CD70 CAR-T Cells CTX131" @default.
- NCIT_C200041 hasExactSynonym "CTX 131" @default.
- NCIT_C200041 hasExactSynonym "CTX-131" @default.
- NCIT_C200041 hasExactSynonym "CTX131" @default.
- NCIT_C200041 hasExactSynonym "Donor-derived Gene-edited Allogeneic CAR-T Cells CTX131" @default.
- NCIT_C200041 inSubset NCIT_C116977 @default.
- NCIT_C200041 inSubset NCIT_C116978 @default.
- NCIT_C200041 inSubset NCIT_C176424 @default.
- NCIT_C200041 type Class @default.
- NCIT_C200041 isDefinedBy ncit.owl @default.
- NCIT_C200041 label "Allogeneic CRISPR-Cas9 Engineered Anti-CD70 CAR-T Cells CTX131" @default.
- NCIT_C200041 subClassOf NCIT_C129820 @default.
- NCIT_C200041 subClassOf NCIT_C129821 @default.
- NCIT_C200041 subClassOf NCIT_C129826 @default.
- NCIT_C200041 subClassOf NCIT_C137999 @default.
- NCIT_C200041 subClassOf NCIT_C142078 @default.
- NCIT_C200041 subClassOf NCIT_C154231 @default.
- NCIT_C200041 subClassOf NCIT_C1908 @default.
- NCIT_C200041 subClassOf NCIT_C1909 @default.
- NCIT_C200041 subClassOf NCIT_C1962 @default.
- NCIT_C200041 subClassOf NCIT_C200041 @default.
- NCIT_C200041 subClassOf NCIT_C200765 @default.
- NCIT_C200041 subClassOf NCIT_C201176 @default.
- NCIT_C200041 subClassOf NCIT_C274 @default.
- NCIT_C200041 subClassOf NCIT_C28676 @default.
- NCIT_C200041 subClassOf NCIT_C307 @default.
- NCIT_C200041 subClassOf NCIT_C308 @default.