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- NCIT_C200045 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the tumor-associated antigen (TAA) carcinoembryonic antigen (CEA; carcinoembryonic antigen-related cell adhesion molecule 5; CEACAM5) and the immune checkpoint regulator carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6; CEACAM-6; CD66c) and conjugated to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic and immune checkpoint inhibitory activities. Upon administration of anti-CEA/CEACAM6 ADC EBC-129, the monoclonal antibody moiety targets and binds to a specific glycosylation site that is conserved on both CEA and CEACAM6 expressed on tumor cells. Upon binding and internalization, MMAE is released where it targets and binds to tubulin and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest and apoptosis in CEA and/or CEACAM6-expressing tumor cells. CEA, a member of the CEA family of proteins that plays a key role in cell migration, cell invasion, and cell adhesion, is overexpressed by a variety of cancer cell types. CEACAM6, an immune checkpoint receptor, is associated with tumor-mediated immune suppression. Elevated CEACAM6 expression is associated with advanced tumor stages and poor prognosis." @default.
- NCIT_C200045 NCIT_A7 NCIT_C107471 @default.
- NCIT_C200045 NCIT_A7 NCIT_C16384 @default.
- NCIT_C200045 NCIT_NHC0 "C200045" @default.
- NCIT_C200045 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200045 NCIT_P107 "Anti-CEA/Anti-CEACAM6 Antibody-drug Conjugate EBC-129" @default.
- NCIT_C200045 NCIT_P108 "Anti-CEA/Anti-CEACAM6 Antibody-drug Conjugate EBC-129" @default.
- NCIT_C200045 NCIT_P322 "CTRP" @default.
- NCIT_C200045 NCIT_P322 "GDC" @default.
- NCIT_C200045 NCIT_P399 "812535" @default.
- NCIT_C200045 normalizedInformationContent "100" @default.
- NCIT_C200045 referenceCount "1" @default.
- NCIT_C200045 hasExactSynonym "Anti-CEA/Anti-CEACAM6 ADC EBC-129" @default.
- NCIT_C200045 hasExactSynonym "Anti-CEA/Anti-CEACAM6 Antibody-drug Conjugate EBC-129" @default.
- NCIT_C200045 hasExactSynonym "Anti-CEACAM5/Anti-CEACAM6 Antibody-drug Conjugate EBC-129" @default.
- NCIT_C200045 hasExactSynonym "EBC 129" @default.
- NCIT_C200045 hasExactSynonym "EBC-129" @default.
- NCIT_C200045 hasExactSynonym "EBC129" @default.
- NCIT_C200045 inSubset NCIT_C116977 @default.
- NCIT_C200045 inSubset NCIT_C116978 @default.
- NCIT_C200045 inSubset NCIT_C128784 @default.
- NCIT_C200045 inSubset NCIT_C157711 @default.
- NCIT_C200045 inSubset NCIT_C157712 @default.
- NCIT_C200045 inSubset NCIT_C176424 @default.
- NCIT_C200045 type Class @default.
- NCIT_C200045 isDefinedBy ncit.owl @default.
- NCIT_C200045 label "Anti-CEA/Anti-CEACAM6 Antibody-drug Conjugate EBC-129" @default.
- NCIT_C200045 subClassOf NCIT_C129821 @default.
- NCIT_C200045 subClassOf NCIT_C129823 @default.
- NCIT_C200045 subClassOf NCIT_C1512 @default.
- NCIT_C200045 subClassOf NCIT_C163758 @default.
- NCIT_C200045 subClassOf NCIT_C1908 @default.
- NCIT_C200045 subClassOf NCIT_C1909 @default.
- NCIT_C200045 subClassOf NCIT_C200043 @default.
- NCIT_C200045 subClassOf NCIT_C200045 @default.
- NCIT_C200045 subClassOf NCIT_C201549 @default.
- NCIT_C200045 subClassOf NCIT_C274 @default.
- NCIT_C200045 subClassOf NCIT_C307 @default.
- NCIT_C200045 subClassOf NCIT_C308 @default.