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- NCIT_C200056 IAO_0000115 "An orally bioavailable, targeted degrader of Bruton's tyrosine kinase (BTK; Bruton agammaglobulinemia tyrosine kinase) comprised of an E3 ubiquitin ligase binding moiety conjugated, via a linker, to a BTK-binding moiety, with potential antineoplastic activity. Upon oral administration of BTK degrader ABBV-101, the BTK-targeting moiety targets and binds to BTK, and the E3 ligase-binding moiety targets and binds to E3 ubiquitin ligase. This catalyzes ubiquitination and proteasome-mediated degradation of BTK, and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival." @default.
- NCIT_C200056 NCIT_A7 NCIT_C75017 @default.
- NCIT_C200056 NCIT_NHC0 "C200056" @default.
- NCIT_C200056 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200056 NCIT_P107 "BTK Degrader ABBV-101" @default.
- NCIT_C200056 NCIT_P108 "BTK Degrader ABBV-101" @default.
- NCIT_C200056 NCIT_P322 "CTRP" @default.
- NCIT_C200056 NCIT_P322 "GDC" @default.
- NCIT_C200056 NCIT_P399 "812794" @default.
- NCIT_C200056 NCIT_R125 NCIT_C17828 @default.
- NCIT_C200056 NCIT_R125 NCIT_C20150 @default.
- NCIT_C200056 NCIT_R125 NCIT_C20480 @default.
- NCIT_C200056 NCIT_R125 NCIT_C40715 @default.
- NCIT_C200056 NCIT_R125 NCIT_C41515 @default.
- NCIT_C200056 NCIT_R125 NCIT_C51037 @default.
- NCIT_C200056 normalizedInformationContent "100" @default.
- NCIT_C200056 referenceCount "1" @default.
- NCIT_C200056 hasExactSynonym "ABBV 101" @default.
- NCIT_C200056 hasExactSynonym "ABBV-101" @default.
- NCIT_C200056 hasExactSynonym "ABBV101" @default.
- NCIT_C200056 hasExactSynonym "BTK Degrader ABBV-101" @default.
- NCIT_C200056 inSubset NCIT_C116977 @default.
- NCIT_C200056 inSubset NCIT_C116978 @default.
- NCIT_C200056 inSubset NCIT_C128784 @default.
- NCIT_C200056 inSubset NCIT_C157711 @default.
- NCIT_C200056 inSubset NCIT_C157712 @default.
- NCIT_C200056 inSubset NCIT_C176424 @default.
- NCIT_C200056 type Class @default.
- NCIT_C200056 isDefinedBy ncit.owl @default.
- NCIT_C200056 label "BTK Degrader ABBV-101" @default.
- NCIT_C200056 subClassOf B1251a55c1b0cf73dcdc7386127f9cfb7 @default.
- NCIT_C200056 subClassOf B5904a169387c69e33d85e51c74e0c531 @default.
- NCIT_C200056 subClassOf NCIT_C1908 @default.
- NCIT_C200056 subClassOf NCIT_C1909 @default.
- NCIT_C200056 subClassOf NCIT_C200055 @default.
- NCIT_C200056 subClassOf NCIT_C200056 @default.
- NCIT_C200056 subClassOf NCIT_C2189 @default.
- NCIT_C200056 subClassOf NCIT_C274 @default.