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- NCIT_C200057 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a human monoclonal antibody targeting folate receptor alpha (FRa; FolRa; FOLR1) conjugated to a camptothecin-based topoisomerase 1 inhibitor AZ14170132, with potential antineoplastic activity. Upon administration of anti-FRa ADC AZD5335, the antibody moiety targets and binds to FRa expressed on tumor cells. Upon binding, cellular uptake and linker cleavage, AZ14170132 is released. AZ14170132 inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and generating DNA single- and double-strand breaks, and leading to cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation of FRa-expressing tumor cells. FRa is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues." @default.
- NCIT_C200057 NCIT_A7 NCIT_C39284 @default.
- NCIT_C200057 NCIT_NHC0 "C200057" @default.
- NCIT_C200057 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200057 NCIT_P107 "Anti-FRa Antibody-drug Conjugate AZD5335" @default.
- NCIT_C200057 NCIT_P108 "Anti-FRa Antibody-drug Conjugate AZD5335" @default.
- NCIT_C200057 NCIT_P322 "CTRP" @default.
- NCIT_C200057 NCIT_P322 "GDC" @default.
- NCIT_C200057 NCIT_P399 "812793" @default.
- NCIT_C200057 normalizedInformationContent "100" @default.
- NCIT_C200057 referenceCount "1" @default.
- NCIT_C200057 hasExactSynonym "AZD 5335" @default.
- NCIT_C200057 hasExactSynonym "AZD-5335" @default.
- NCIT_C200057 hasExactSynonym "AZD5335" @default.
- NCIT_C200057 hasExactSynonym "Anti-FRa ADC AZD5335" @default.
- NCIT_C200057 hasExactSynonym "Anti-FRa Antibody-drug Conjugate AZD5335" @default.
- NCIT_C200057 hasExactSynonym "Anti-folate Receptor Alpha Antibody-drug Conjugate AZD5335" @default.
- NCIT_C200057 inSubset NCIT_C116977 @default.
- NCIT_C200057 inSubset NCIT_C116978 @default.
- NCIT_C200057 inSubset NCIT_C128784 @default.
- NCIT_C200057 inSubset NCIT_C157711 @default.
- NCIT_C200057 inSubset NCIT_C157712 @default.
- NCIT_C200057 inSubset NCIT_C176424 @default.
- NCIT_C200057 type Class @default.
- NCIT_C200057 isDefinedBy ncit.owl @default.
- NCIT_C200057 label "Anti-FRa Antibody-drug Conjugate AZD5335" @default.
- NCIT_C200057 subClassOf NCIT_C129821 @default.
- NCIT_C200057 subClassOf NCIT_C129823 @default.
- NCIT_C200057 subClassOf NCIT_C1512 @default.
- NCIT_C200057 subClassOf NCIT_C163758 @default.
- NCIT_C200057 subClassOf NCIT_C1908 @default.
- NCIT_C200057 subClassOf NCIT_C1909 @default.
- NCIT_C200057 subClassOf NCIT_C200057 @default.
- NCIT_C200057 subClassOf NCIT_C200086 @default.
- NCIT_C200057 subClassOf NCIT_C200114 @default.
- NCIT_C200057 subClassOf NCIT_C274 @default.
- NCIT_C200057 subClassOf NCIT_C307 @default.
- NCIT_C200057 subClassOf NCIT_C308 @default.