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- NCIT_C200070 IAO_0000115 "A half-life extended T-cell engaging bispecific antibody comprised of a single chain variable fragment (scFv) targeting the tumor-associated antigen (TAA) CD19, a scFv targeting the T-cell surface antigen CD3, and a single-domain heavy chain variable domain (VHH)-based antibody specific for human serum albumin (HSA), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19/CD3 T-cell engaging bispecific antibody CLN-978 targets and binds to both CD19 antigen expressed on tumor cells and CD3 antigen expressed on T-cells. This results in the cross-linking of T-cells and tumor cells, and induces a cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies. The HSA binding domain prolongs the half-life of CLN-978." @default.
- NCIT_C200070 NCIT_A7 NCIT_C38894 @default.
- NCIT_C200070 NCIT_NHC0 "C200070" @default.
- NCIT_C200070 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C200070 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200070 NCIT_P107 "Anti-CD19/CD3 T-cell Engaging Bispecific Antibody CLN-978" @default.
- NCIT_C200070 NCIT_P108 "Anti-CD19/CD3 T-cell Engaging Bispecific Antibody CLN-978" @default.
- NCIT_C200070 NCIT_P322 "CTRP" @default.
- NCIT_C200070 NCIT_P322 "GDC" @default.
- NCIT_C200070 NCIT_P399 "812976" @default.
- NCIT_C200070 NCIT_R124 NCIT_C17710 @default.
- NCIT_C200070 NCIT_R124 NCIT_C17828 @default.
- NCIT_C200070 NCIT_R124 NCIT_C18219 @default.
- NCIT_C200070 NCIT_R124 NCIT_C19986 @default.
- NCIT_C200070 NCIT_R124 NCIT_C40474 @default.
- NCIT_C200070 normalizedInformationContent "100" @default.
- NCIT_C200070 referenceCount "1" @default.
- NCIT_C200070 hasExactSynonym "Anti-CD19/Anti-CD3 T-cell Engaging Bispecific Antibody CLN-978" @default.
- NCIT_C200070 hasExactSynonym "Anti-CD19/CD3 T-cell Engaging Bispecific Antibody CLN-978" @default.
- NCIT_C200070 hasExactSynonym "CD19xCD3 T-cell Engager CLN-978" @default.
- NCIT_C200070 hasExactSynonym "CLN 978" @default.
- NCIT_C200070 hasExactSynonym "CLN-978" @default.
- NCIT_C200070 hasExactSynonym "CLN978" @default.
- NCIT_C200070 inSubset NCIT_C116977 @default.
- NCIT_C200070 inSubset NCIT_C116978 @default.
- NCIT_C200070 inSubset NCIT_C128784 @default.
- NCIT_C200070 inSubset NCIT_C157711 @default.
- NCIT_C200070 inSubset NCIT_C157712 @default.
- NCIT_C200070 inSubset NCIT_C176424 @default.
- NCIT_C200070 type Class @default.
- NCIT_C200070 isDefinedBy ncit.owl @default.
- NCIT_C200070 label "Anti-CD19/CD3 T-cell Engaging Bispecific Antibody CLN-978" @default.
- NCIT_C200070 subClassOf NCIT_C112883 @default.
- NCIT_C200070 subClassOf NCIT_C112889 @default.
- NCIT_C200070 subClassOf NCIT_C129820 @default.
- NCIT_C200070 subClassOf NCIT_C129821 @default.
- NCIT_C200070 subClassOf NCIT_C129822 @default.
- NCIT_C200070 subClassOf NCIT_C1454 @default.
- NCIT_C200070 subClassOf NCIT_C163758 @default.
- NCIT_C200070 subClassOf NCIT_C1908 @default.
- NCIT_C200070 subClassOf NCIT_C1909 @default.
- NCIT_C200070 subClassOf NCIT_C198634 @default.
- NCIT_C200070 subClassOf NCIT_C200070 @default.
- NCIT_C200070 subClassOf NCIT_C201282 @default.
- NCIT_C200070 subClassOf NCIT_C20401 @default.
- NCIT_C200070 subClassOf NCIT_C274 @default.
- NCIT_C200070 subClassOf NCIT_C28227 @default.
- NCIT_C200070 subClassOf NCIT_C307 @default.
- NCIT_C200070 subClassOf NCIT_C308 @default.