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- NCIT_C200071 IAO_0000115 "A preparation of autologous T-lymphocytes that have been genetically modified to express a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-A*02:01-restricted TP53 (p53) R175H mutant, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and re-introduction into the patient, the autologous TP53 R175H mutant-specific HLA-A*02:01-restricted TCR gene engineered T-lymphocytes NT-175 target and bind to tumor cells expressing the TP53 R175H mutant. This may lead to cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the TP53 R175H mutant. p53, a tumor suppressor gene, is mutated in many tumor cells, resulting in the loss of apoptosis regulation and abnormal cell proliferation." @default.
- NCIT_C200071 NCIT_A7 NCIT_C146886 @default.
- NCIT_C200071 NCIT_NHC0 "C200071" @default.
- NCIT_C200071 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200071 NCIT_P107 "Autologous TP53 R175H Mutant-specific HLA-A*02:01-restricted TCR Gene Engineered T-lymphocytes NT-175" @default.
- NCIT_C200071 NCIT_P108 "Autologous TP53 R175H Mutant-specific HLA-A*02:01-restricted TCR Gene Engineered T-lymphocytes NT-175" @default.
- NCIT_C200071 NCIT_P322 "CTRP" @default.
- NCIT_C200071 NCIT_P322 "GDC" @default.
- NCIT_C200071 NCIT_P399 "812977" @default.
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- NCIT_C200071 NCIT_R72 NCIT_C12535 @default.
- NCIT_C200071 NCIT_R72 NCIT_C12542 @default.
- NCIT_C200071 NCIT_R72 NCIT_C12543 @default.
- NCIT_C200071 NCIT_R72 NCIT_C21599 @default.
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- NCIT_C200071 NCIT_R72 NCIT_C39567 @default.
- NCIT_C200071 NCIT_R72 NCIT_C39568 @default.
- NCIT_C200071 normalizedInformationContent "100" @default.
- NCIT_C200071 referenceCount "1" @default.
- NCIT_C200071 hasExactSynonym "Autologous P53-specific TCR-T Cells NT-175" @default.
- NCIT_C200071 hasExactSynonym "Autologous TP53 R175H Mutant-specific HLA-A*02:01-restricted TCR Gene Engineered T-lymphocytes NT-175" @default.
- NCIT_C200071 hasExactSynonym "Autologous TP53 R175H Mutant-specific HLA-A*02:01-restricted TCR T Cells NT-175" @default.
- NCIT_C200071 hasExactSynonym "NT 175" @default.
- NCIT_C200071 hasExactSynonym "NT-175" @default.
- NCIT_C200071 hasExactSynonym "NT175" @default.
- NCIT_C200071 inSubset NCIT_C116977 @default.
- NCIT_C200071 inSubset NCIT_C116978 @default.
- NCIT_C200071 inSubset NCIT_C128784 @default.
- NCIT_C200071 inSubset NCIT_C157711 @default.
- NCIT_C200071 inSubset NCIT_C157712 @default.
- NCIT_C200071 inSubset NCIT_C176424 @default.
- NCIT_C200071 type Class @default.
- NCIT_C200071 isDefinedBy ncit.owl @default.
- NCIT_C200071 label "Autologous TP53 R175H Mutant-specific HLA-A*02:01-restricted TCR Gene Engineered T-lymphocytes NT-175" @default.
- NCIT_C200071 subClassOf NCIT_C129820 @default.
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- NCIT_C200071 subClassOf NCIT_C28681 @default.
- NCIT_C200071 subClassOf NCIT_C307 @default.
- NCIT_C200071 subClassOf NCIT_C308 @default.