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- NCIT_C200072 IAO_0000115 "A preparation of human allogeneic T-lymphocytes transduced with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, and modified ex vivo to disrupt the expression of major histocompatibility (MHC) class I and MHC class II molecules and to express CD47, with potential immunomodulating and antineoplastic activities. Upon introduction into the patient, the allogeneic hypoimmune anti-CD19 CAR T-cells SC291 recognize and bind to CD19-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The disruption of MHC class I and MHC class II molecules and the expression of CD47 prevent immune response against the allogeneic CAR T-cells, thereby increasing the persistence of the CAR T-cells." @default.
- NCIT_C200072 NCIT_A7 NCIT_C38894 @default.
- NCIT_C200072 NCIT_NHC0 "C200072" @default.
- NCIT_C200072 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200072 NCIT_P107 "Allogeneic Hypoimmune Anti-CD19 CAR T-cells SC291" @default.
- NCIT_C200072 NCIT_P108 "Allogeneic Hypoimmune Anti-CD19 CAR T-cells SC291" @default.
- NCIT_C200072 NCIT_P322 "CTRP" @default.
- NCIT_C200072 NCIT_P322 "GDC" @default.
- NCIT_C200072 NCIT_P399 "812978" @default.
- NCIT_C200072 normalizedInformationContent "100" @default.
- NCIT_C200072 referenceCount "1" @default.
- NCIT_C200072 hasExactSynonym "Allogeneic Anti-CD19 CAR T Cells SC291" @default.
- NCIT_C200072 hasExactSynonym "Allogeneic HIP Anti-CD19 CAR-T Cells SC291" @default.
- NCIT_C200072 hasExactSynonym "Allogeneic Hypoimmune Anti-CD19 CAR T-cells SC291" @default.
- NCIT_C200072 hasExactSynonym "SC 291" @default.
- NCIT_C200072 hasExactSynonym "SC-291" @default.
- NCIT_C200072 hasExactSynonym "SC291" @default.
- NCIT_C200072 inSubset NCIT_C116977 @default.
- NCIT_C200072 inSubset NCIT_C116978 @default.
- NCIT_C200072 inSubset NCIT_C128784 @default.
- NCIT_C200072 inSubset NCIT_C157711 @default.
- NCIT_C200072 inSubset NCIT_C157712 @default.
- NCIT_C200072 inSubset NCIT_C176424 @default.
- NCIT_C200072 type Class @default.
- NCIT_C200072 isDefinedBy ncit.owl @default.
- NCIT_C200072 label "Allogeneic Hypoimmune Anti-CD19 CAR T-cells SC291" @default.
- NCIT_C200072 subClassOf NCIT_C129820 @default.
- NCIT_C200072 subClassOf NCIT_C129821 @default.
- NCIT_C200072 subClassOf NCIT_C129826 @default.
- NCIT_C200072 subClassOf NCIT_C137999 @default.
- NCIT_C200072 subClassOf NCIT_C142078 @default.
- NCIT_C200072 subClassOf NCIT_C154231 @default.
- NCIT_C200072 subClassOf NCIT_C176018 @default.
- NCIT_C200072 subClassOf NCIT_C1908 @default.
- NCIT_C200072 subClassOf NCIT_C1909 @default.
- NCIT_C200072 subClassOf NCIT_C1962 @default.
- NCIT_C200072 subClassOf NCIT_C200072 @default.
- NCIT_C200072 subClassOf NCIT_C200765 @default.
- NCIT_C200072 subClassOf NCIT_C274 @default.
- NCIT_C200072 subClassOf NCIT_C28676 @default.
- NCIT_C200072 subClassOf NCIT_C307 @default.
- NCIT_C200072 subClassOf NCIT_C308 @default.