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- NCIT_C200082 IAO_0000115 "A conditionally active biologic (CAB) and bispecific antibody directed against both the tumor-associated antigen (TAA) human epithelial cell adhesion molecule (Ep-CAM; EpCAM; CD326) and T-cell surface glycoprotein CD3 epsilon chain (CD3E), with potential immunomodulating and antineoplastic activities. Upon administration and specific activation in the tumor microenvironment (TME), anti-EpCAM/anti-CD3 bispecific antibody BA3182 targets and binds to both EpCAM on EpCAM-expressing tumor cells and CD3E on cytotoxic T-lymphocytes (CTLs) within the TME. This activates and redirects CTLs to EpCAM-expressing tumor cells, which results in the CTL-mediated cell death of EpCAM-expressing tumor cells. EpCAM, a cell surface protein upregulated on many tumor cell types, promotes the proliferation, migration and invasiveness of tumor cells. Negatively charged, physiologically-occurring molecules interact with positively charged areas on the protein surface to prevent the activation of BA3182 outside the TME. In the acidic TME, the negatively charged molecules are neutralized and released, allowing the binding to EpCAM and CD3E. This may reduce systemic toxicity." @default.
- NCIT_C200082 NCIT_A7 NCIT_C20209 @default.
- NCIT_C200082 NCIT_NHC0 "C200082" @default.
- NCIT_C200082 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200082 NCIT_P107 "Anti-EpCAM/Anti-CD3 Bispecific Antibody BA3182" @default.
- NCIT_C200082 NCIT_P108 "Anti-EpCAM/Anti-CD3 Bispecific Antibody BA3182" @default.
- NCIT_C200082 NCIT_P322 "CTRP" @default.
- NCIT_C200082 NCIT_P322 "GDC" @default.
- NCIT_C200082 NCIT_P399 "812923" @default.
- NCIT_C200082 NCIT_R124 NCIT_C17710 @default.
- NCIT_C200082 NCIT_R124 NCIT_C17828 @default.
- NCIT_C200082 NCIT_R124 NCIT_C18219 @default.
- NCIT_C200082 NCIT_R124 NCIT_C19986 @default.
- NCIT_C200082 NCIT_R124 NCIT_C40474 @default.
- NCIT_C200082 normalizedInformationContent "100" @default.
- NCIT_C200082 referenceCount "1" @default.
- NCIT_C200082 hasExactSynonym "Anti-EpCAM/Anti-CD3 Bispecific Antibody BA3182" @default.
- NCIT_C200082 hasExactSynonym "Anti-EpCAM/CD3 Bispecific Antibody BA3182" @default.
- NCIT_C200082 hasExactSynonym "Anti-EpCAM/CD3 CAB-bispecific T-cell Engager Antibody BA3182" @default.
- NCIT_C200082 hasExactSynonym "BA 3182" @default.
- NCIT_C200082 hasExactSynonym "BA-3182" @default.
- NCIT_C200082 hasExactSynonym "BA3182" @default.
- NCIT_C200082 hasExactSynonym "EpCAM x CD3 Bispecific Antibody BA3182" @default.
- NCIT_C200082 inSubset NCIT_C116977 @default.
- NCIT_C200082 inSubset NCIT_C116978 @default.
- NCIT_C200082 inSubset NCIT_C128784 @default.
- NCIT_C200082 inSubset NCIT_C157711 @default.
- NCIT_C200082 inSubset NCIT_C157712 @default.
- NCIT_C200082 inSubset NCIT_C176424 @default.
- NCIT_C200082 type Class @default.
- NCIT_C200082 isDefinedBy ncit.owl @default.
- NCIT_C200082 label "Anti-EpCAM/Anti-CD3 Bispecific Antibody BA3182" @default.
- NCIT_C200082 subClassOf NCIT_C112883 @default.
- NCIT_C200082 subClassOf NCIT_C129821 @default.
- NCIT_C200082 subClassOf NCIT_C129822 @default.
- NCIT_C200082 subClassOf NCIT_C1454 @default.
- NCIT_C200082 subClassOf NCIT_C1908 @default.
- NCIT_C200082 subClassOf NCIT_C1909 @default.
- NCIT_C200082 subClassOf NCIT_C200082 @default.
- NCIT_C200082 subClassOf NCIT_C201282 @default.
- NCIT_C200082 subClassOf NCIT_C201523 @default.
- NCIT_C200082 subClassOf NCIT_C20401 @default.
- NCIT_C200082 subClassOf NCIT_C274 @default.
- NCIT_C200082 subClassOf NCIT_C28227 @default.
- NCIT_C200082 subClassOf NCIT_C307 @default.
- NCIT_C200082 subClassOf NCIT_C308 @default.