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- NCIT_C200126 IAO_0000115 "An antibody-drug conjugate (ADC) consisting of a human monoclonal antibody directed against the tumor-associated antigen (TAA) cluster of differentiation 70 (CD70), conjugated via a cleavable, hydrophilic linker to the camptothecin analog exatecan, with potential antineoplastic activity. Upon administration of anti-CD70 ADC PRO1160, the anti-CD70 antibody moiety targets and binds to CD70-expressing tumor cells. Upon binding, internalization and linker cleavage, exatecan is released. Exatecan inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation of CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on the surfaces of various types of cancer cells." @default.
- NCIT_C200126 NCIT_A7 NCIT_C104079 @default.
- NCIT_C200126 NCIT_NHC0 "C200126" @default.
- NCIT_C200126 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C200126 NCIT_P108 "Anti-CD70 Antibody-drug Conjugate PRO1160" @default.
- NCIT_C200126 NCIT_P322 "GDC" @default.
- NCIT_C200126 NCIT_P399 "812571" @default.
- NCIT_C200126 normalizedInformationContent "100" @default.
- NCIT_C200126 referenceCount "1" @default.
- NCIT_C200126 hasExactSynonym "Anti-CD70 ADC PRO1160" @default.
- NCIT_C200126 hasExactSynonym "Anti-CD70 Antibody-drug Conjugate PRO1160" @default.
- NCIT_C200126 hasExactSynonym "PRO 1160" @default.
- NCIT_C200126 hasExactSynonym "PRO-1160" @default.
- NCIT_C200126 hasExactSynonym "PRO1160" @default.
- NCIT_C200126 inSubset NCIT_C128784 @default.
- NCIT_C200126 inSubset NCIT_C157711 @default.
- NCIT_C200126 inSubset NCIT_C157712 @default.
- NCIT_C200126 inSubset NCIT_C176424 @default.
- NCIT_C200126 type Class @default.
- NCIT_C200126 isDefinedBy ncit.owl @default.
- NCIT_C200126 label "Anti-CD70 Antibody-drug Conjugate PRO1160" @default.
- NCIT_C200126 subClassOf NCIT_C129821 @default.
- NCIT_C200126 subClassOf NCIT_C129823 @default.
- NCIT_C200126 subClassOf NCIT_C1512 @default.
- NCIT_C200126 subClassOf NCIT_C163758 @default.
- NCIT_C200126 subClassOf NCIT_C1908 @default.
- NCIT_C200126 subClassOf NCIT_C1909 @default.
- NCIT_C200126 subClassOf NCIT_C200042 @default.
- NCIT_C200126 subClassOf NCIT_C200126 @default.
- NCIT_C200126 subClassOf NCIT_C201550 @default.
- NCIT_C200126 subClassOf NCIT_C274 @default.
- NCIT_C200126 subClassOf NCIT_C307 @default.
- NCIT_C200126 subClassOf NCIT_C308 @default.